Buffering effects of non-invasive vagus nerve stimulation on stress-induced psychobiological alterations: a placebo-controlled trial in normal-weight and obese subjects
- Conditions
- stressE66.90E66.91
- Registration Number
- DRKS00007991
- Lead Sponsor
- niversität ZürichPsychologisches InstitutKlinische Psychologie und Psychotherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 165
1. Male sex
2. Age range from 18-38 years
3. Good knowledge of the German language
4. BMI between 18.5 and 25 kg/m2 or between 28 and 40 kg/m2
1. Acute and/or chronic somatic diseases
2. Mental disorders.
3. Known sensitivity of the head to cold, pressure, and draft
4. Medication intake or substance abuse in the last two months
5. Consumption of psychedelic drugs in the last four weeks
6. Excessive consumption of alcohol (more than 2 beverages p.d.)
7. Consumption of tobacco (more than 10 cigarettes p.d.)
8. Bodybuilding (more than 3 hours a week)
9. Wearing pacemakers, defibrillators, and cochlear and/or metal implants
10. Blood donation or significant blood loss (due to accident or surgery) in the last three months
11. Long-distance flight in the past two weeks
12. Shift work
13. Participation in a previous stress study or concomitant participation in other intervention studies
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Outcome: Stress reactiviy<br>Messung: physiological measures (hormones: cortisol, testosteron, progestoren, estradiol, inflammtion: cytokines, C-reactive protein, metabolic: Insulin, glucose, cardio vascular: heart rate, heart rate variability)<br>Time points: before, during and after stress tests
- Secondary Outcome Measures
Name Time Method Psychological tests: Empathy, implicite motives, interoception and further questionnaires.<br><br>Further physiological measures: Waist-to-Hip, resting metabolic rate, bio impedance