Quadratus Lumborum Block for Total Hip Arthroplasty

Early Phase 1

Recruiting

• Conditions: Pain, Postoperative
• Interventions: Drug: Active Comparator; Drug: Placebo Comparator

• Registration Number: NCT05247255
• Lead Sponsor: University of California, Los Angeles

Brief Summary

The quadratus lumborum (QL) block is a fascial plane block that has been described to provide analgesia from T7-L3 dermatomes. The investigators aim to evaluate the efficacy of QL blocks in patients undergoing primary total hip arthroplasty (THA).

Detailed Description

Investigators will enroll subjects planned for primary THA and allocate them into receiving a QL block with either saline or ropivacaine. Primary outcome will be pain scores over the first 48 hours after surgery.

Study Timeline

• Study First Submitted: 2022-01-30
• Study First Submitted QC: 2022-02-09
• Study First Posted: 2022-02-18
• Study Start: 2022-03-29
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-18
• Last Update Posted: 2024-12-20
• Primary Completion: 2026-12
• Study Completion: 2027-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Adult subjects undergoing elective primary total hip arthroplasty

Exclusion Criteria

• patients age < 18,
• documented allergy to local anesthetic
• presence of peripheral neuropathy
• patients with current long term opioid use defined as receiving an opioid on most days in a 90 day period
• patients with a contraindication to spinal and regional anesthesia such as coagulopathy or infection at the site of the regional technique.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention Group	Active Comparator	Quadratus lumborum nerve block with 0.25% ropivacaine
Control Group	Placebo Comparator	Quadratus lumborum nerve block with saline

Primary Outcome Measures

Name	Time	Method
Pain score	Up to 48 hrs post op	Pain scores will be assessed over 48hrs postop using the visual analog score

Secondary Outcome Measures

Name	Time	Method
Time to first ambulation	Up to 1 week post surgery	Time to first ambulation of 50 feet or more, with or without the help of assist devices (i.e. walker, cane) or staff assistance.
Ambulation distance	Up to 1 week post surgery	This data point will be measured in feet and will be determined by the distance ambulated during the patient's first ambulation attempt after surgery, regardless of the length of ambulation (This distance will be counted regardless of whether the patient reaches the 50 feet requirement to be counted as the "time to first ambulation).
Patient satisfaction	Until day of discharge from the hospital, up to 1 week post surgery	Patient satisfaction score will be assessed on day of discharge as measured by a 5-point scale with 1 = terrible, 2 = poor, 3 = satisfactory, 4 = good, and 5 = excellent.
Opioid usage	Up to 48 hrs post op	Total morphine-equivalent will be calculated at 0-24hrs and 24-48hrs postop.
Time to first stand	Up to 1 week post surgery	The period between the end of surgery and the patient's first successful attempt at standing, with or without the assistance of devices (i.e. walker, cane) or staff assistance.
Length of hospital stay	Until discharge from hospital, up to 1 week post surgery	Number of days in the hospital from postoperative day 0 to discharge

Trial Locations

Locations (1)

UCLA Medical Center, Santa Monica; 🇺🇸 Santa Monica, California, United States