Renal Sympathetic Denervation in Patients With Mild Refractory Hypertension

University of Leipzig1 site in 1 country71 target enrollmentJuly 2012

Overview

The purpose of this study is to examine the benefit of renal sympathetic denervation in patients with mild refractory hypertension

Registry

clinicaltrials.gov

Start Date

July 2012

End Date

July 2014

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Sponsor

University of Leipzig

Responsible Party

Principal Investigator

Steffen Desch, MD

Principal Investigator

University of Leipzig

•Refractory hypertension: 3 or more antihypertensive agents of different classes (including a diuretic) at optimal dosage without change in the 4 weeks preceding randomization
•Systolic blood pressure of 135-149 and/or diastolic blood pressure of 90-94 mmHg (ABPM mean daytime values)
•No change in blood pressure medication within 6 months after randomization
•Age 18 to 75 years
•Informed consent

•Blood pressure outside range mentioned above
•Renal, aortic or pelvic anatomy unsuited for renal sympathetic denervation
•Estimated glomerular filtration rate \<45 mL/min/1.73 m² (modification of diet in renal disease formula)
•Unstable angina pectoris
•Myocardial infarction within 6 months prior to randomization
•Planned surgery or cardiovascular intervention within 6 months after randomization
•Severe heart valve disease
•Severe comorbidities with limited life expectancy
•Pregnancy
•Participation in another trial