Exploring the effect of a novel brain stimulation technique on cognitive function in people with early Alzheimer’s disease and amnestic mild cognitive impairment- A double-blinded randomised placebo-controlled delayed-start pilot study

niversity of Otago0 sites24 target enrollmentFebruary 25, 2022

Overview

No summary available.

Registry

who.int

Start Date

February 25, 2022

End Date

TBD

Last Updated

4 years ago

Study Type

Interventional

Sex

All

Sponsor

•To be included in the study, participants must meet all of the following inclusion criteria:
•Capable of understanding and signing an informed consent form, as assessed by the informed consent questionnaire.
•A diagnosis of ‘probable’ or ‘possible’ Alzheimer’s disease based on National Institute on Aging and Alzheimer’s Association (NIA\-AA) guidelines or a diagnosis of amnestic mild cognitive impairment
•A score of 0\.5\-1 in the Clinical Dementia Rating scale
•A score of 72 points or higher on the Addenbrooke’s Cognitive Examination (ACE\-III, a screening instrument for dementia)
•A score higher than 18 points in the Mini\-Mental State Exam (MMSE)

•Participants who meet any of the following conditions will be excluded:
•History of epilepsy or seizures
•History of stroke or tumour
•Unstable medical or psychiatric conditions
•Presence of any pacemaker or defibrillator
•Presence of any metal implant in the body
•Alcohol or substance abuse
•Dyslipidaemia
•History of uncontrolled/untreated hypertension
•Participants who, in the opinion of the investigators, do not understand the information and procedures of the study, or would not be compliant with them.