Effects of Estrogen therapy on Ghrelin and Leptin level in overweight/obese women with surgical menopause

Phase 1

• Conditions: Ghrelin and leptin level in postmenopausal women after two different route of estrogen therapy; Estrogen; Ghrelin; Leptin; Obese; Bodyweight; Body composition

• Registration Number: TCTR20210831004
• Lead Sponsor: Ratchadapisek sompoch Endowment fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-31
• Study Completion: 2022-08-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: Female
• Target Recruitment: 66

Inclusion Criteria

Postmenopausal women who have undergone bilateral oophorectomy before menopause
Within 10 years since menopause
BMI in overweight/obese range (Asian criteria)
No history of menopausal hormonal therapy use or wash out more than 3 months before recruitment

Exclusion Criteria

Premature ovarian insufficiency (onset of menopause before 40 years)
History of cancer, chemotherapy or radiation
History of Type 1 or type 2 diabetes, hypertrigleceridemia, immunocompromised host, abnormal thyroid function
Contraindication to hormonal therapy (stroke, venous thromboembolism, coronary heart disease, breast cancer, drug hypersensitivity)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ghrelin level 12 weeks Blood testing

Secondary Outcome Measures

Name	Time	Method
eptin level 12 weeks Blood testing,Appetite change 12 weeks Questionaire