A study to the effects of 4 toothpastes on the development of dental erosion and the composition of the pellicle

Conditions: tandaandoeningen
dental erosion
wear

Registration Number: NL-OMON33790

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

Adults with an ASA score of 1 with a rehabilited dentition.

Exclusion Criteria

An ASA score of 2 or higher, severe periodontal disease (Dutch periodontal screening indez, DPSI > 2) and an unrehabiliated dentition. Participants wearing a removable appliance in the upper jaw can not participate.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The loss of enamel due to erosion will be determined using Atomic Absorption<br /><br>Spectroscopy (AAS, calcium concentration) and molybdate UV-spectrophometry.<br /><br>With these techniques the loss of enamel can be calculated. Baseline<br /><br>measurements of the eroding solution will be performed. After exposing the<br /><br>samples to the eroding solution the calcium concentration of the solution is<br /><br>measured again. The differences in calcium concentration are an indication of<br /><br>the loss of enamel [Dijkman et al., 1983; Vieira et al., 2005].</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The pellicle adhered to the porcelain attached to the removable appliance will<br /><br>be analysed using SDS-page. The differences in protein composition between a<br /><br>pellicle exposed to toothpaste and normal pellicle will be determined</p><br>