Biology of Cerebral Arteriovenous Malformations : Study of the Link Between Blood Biomarkers and the Haemorrhagic Prognosis of Cerebral Arteriovenous Malformations
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Associaton between dosage of endothelial marker and the arteriovenous malformation pronostic
研究概览
简要总结
The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous circulation.
The cerebral arteriovenous malformations are an important cause of hemorrhagic stroke.
The hypothesis is that cerebral haemorrhage associated with a cerebral arteriovenous malformations would come from peri-nidal micro-vessels, in connection with infiltration of leucocytes and / or defective maintenance of microvascular integrity by platelets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient over 18 years old
- •Patient with a cerebral AVM for which an intervention (endovascular treatment or surgery) or only clinical monitoring
- •Express consent to participate in the study
- •Free informed and express consent of both holders of the minor patient's parental authority, or, by way of derogation and only if the other holder of parental authority cannot give his or her consent within a time limit compatible with the methodological requirements specific to the conduct of the research with regard to its purposes, of one of the two holders of parental authority
排除标准
- •Patient benefiting from a legal protection measure
- •Pregnant or breast feeding woman
结局指标
主要结局
Associaton between dosage of endothelial marker and the arteriovenous malformation pronostic
时间窗: 6 months
associaton between dosage of endothelial marker in blood samples and correlation with clinical outcome
Associaton between dosage of neutrophilic and the arteriovenous malformation pronostic
时间窗: 6 months
Dosage of neutrophilic in blood samples and correlation with clinical outcome
Associaton between dosage of platelet and the arteriovenous malformation pronostic
时间窗: 6 months
Dosage of platelet in blood samples and correlation with clinical outcome
Associaton between neo-angiogenesis activation markers and the arteriovenous malformation pronostic
时间窗: 6 months
Dosage neo-angiogenesis activation markers in blood samples and correlation with clinical outcome
次要结局
未报告次要终点