ISRCTN62125126已完成未知
A pharmacokinetic investigation into the formation of carbamazepine metabolites and carbamazepine-protein conjugates in epilepsy patients
niversity of Liverpool0 个研究点目标入组 158 人开始时间: 2015年2月19日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 158
研究概览
简要总结
2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33217013/ (added 21/09/2021)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Autoinduction group:
- •1. Subject is willing and able to give written informed consent
- •2. Subject is aged 18 or over
- •3.Subject is newly prescribed carbamazepine by their attending physician
- •Maintenance group:
- •1. Subject is willing and able to give written informed consent
- •2. Subject is aged 18 or over
- •3. Subject has received CBZ therapy at the same dosage for at least 4 weeks
排除标准
- •Autoinduction group:
- •1. Subject is not willing to take part or unable to give written informed consent
- •2. Subject has in the past 4 weeks received other medication that is a CYP3A4 inducer or inhibitor (see medications below)
- •3. Subject has taken part on another research study within 90 days of commencement
- •4. Subject has any condition which in the opinion of the investigator will interfere with the study
- •Excluded medications:
- •Rifampicin, Amiodarone, Fluvoxamine, Saquinavir, Rifampin, Amprenavir, Indinavir, SVerapamil, Isoniazid, Atazanavir, Lopinavir, Verapamil, Phenytoin, Azithromycin, Mifepristone, Phenobarbital, Grapefruit juice, Nelfinavir, Omeprazole, Clarithromycin, Norverapamil, Clotrimazole, Cyclosporine A, Ritonavir, HMGCoA reductase inhibitors, Delavirdine, Ndesmethylerythromycin, Cyclophosphamide, Erythromycin, Roxithromycin, Spironolactone, Fluoxetine, RVerapamil
- •Maintenance group:
- •1. Subject is not willing to take part or unable to give written informed consent
- •2. Subject has any condition which in the opinion of the investigator will interfere with the study
研究者
相似试验
已完成
不适用
Pharmacokinetic investigation into the formation of carbamazepine metabolites and carbamazepine-protein conjugates in healthy volunteersISRCTN00131154Royal Liverpool and Broadgreen University NHS Trust (UK)8
已完成
1 期
A Study to Assess the Effect of Hepatic Impairment on Safinamide PharmacokineticsHepatic ImpairmentNCT01027169Newron Pharmaceuticals SPA24
招募中
3 期
Various types of meropenem administration in patients with VAP snd ARCIRCT20130917014693N12Shahid Beheshti University of Medical Sciences60
已完成
1 期
Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver FunctionAsthmaNCT00419237GlaxoSmithKline20
已完成
1 期
Study of Pharmacokinetics and Pharmacodynamics of Artesunate in Pregnant Women in the Democratic Republic of CongoMalariaNCT00538382NICHD Global Network for Women's and Children's Health51