Application of an Early In-Hospital Temperature Management Protocol for Heat Stroke Patients
- Conditions
- Heat Stroke
- Interventions
- Other: the early in-hospital temperature management protocol for heat stroke patients
- Registration Number
- NCT06537557
- Lead Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Brief Summary
Heat stroke is a life-threatening clinical syndrome characterized by an imbalance between heat production and heat dissipation in the body, resulting from exposure to hot and humid environments and/or strenuous exercise. It is defined by an elevated core temperature exceeding 40°C and central nervous system abnormalities, accompanied by multi-organ dysfunction. The severity of cellular and tissue damage in heat stroke patients depends on the peak temperature reached and the duration of hyperthermia. Rapid reduction of core temperature can halt cellular damage, quickly reverse organ dysfunction, and improve patient outcomes. Therefore, early identification and rapid cooling are crucial to prevent irreversible damage and death in heat stroke patients. However, there is a lack of systematic and specific protocols to guide emergency medical staff in the standardized and effective management of body temperature in heat stroke patients. To address this, our research team previously developed an early in-hospital temperature management protocol for heat stroke patients based on the best available evidence, expert consultations, and expert panel meetings. This study aims to validate the feasibility and effectiveness of the protocol through clinical research, providing a basis for clinical practice.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 188
- Patients admitted to the emergency department and diagnosed with heat stroke according to the China expert consensus on Heat Stroke
- transferred from another hospital and body temperature < 39.5℃; discharged within 4 hours, and subsequent body temperature or outcomes were unavailable; required immediate cardiopulmonary resuscitation; had other serious diseases, such as massive cerebral haemorrhage or severe trauma.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description experimental group the early in-hospital temperature management protocol for heat stroke patients Using the early in-hospital temperature management protocol for heat stroke patients developed in our previous research, we will implement early identification, rapid cooling, and precise target temperature management for this group of patients.
- Primary Outcome Measures
Name Time Method cooling rate at 0.5 hours 0.5 hours The cooling rate at 0.5 hours was calculated in reference to initial body temperature and body temperature at 0.5 hours
Body temperature at 0.5 hours 0.5 hours Body temperature at 0.5 hour refers to a reading obtained 25 to 35 minutes after admission.
- Secondary Outcome Measures
Name Time Method Body temperature at 2 hours 2 hours Body temperature at 2 hours refers to a reading taken 100 to 140 minutes after admission
in-hospital mortality 30 days Mortality from any cause during hospitalization
3-month mortality rate 3 months death within 3 months after emergency visit
Number of participants with other complications 3 months including heart failure, renal failure, coagulation disorders, respiratory failure, neurological sequelae, etc.
Trial Locations
- Locations (7)
Yongkang First People's Hospital
🇨🇳Yongkang, Zhejiang, China
Dongyang People's Hospital
🇨🇳Dongyang, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hanzhou, China
Jinhua Municipal Central Hospital
🇨🇳Jinhua, China
Jinhua People's Hospital
🇨🇳Jinhua, China
Lanxi People's Hospital
🇨🇳Lanxi, China
Yiwu Central Hospital
🇨🇳Yiwu, China