Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
- Conditions
- Crohn's Disease
- Interventions
- Registration Number
- NCT06548542
- Lead Sponsor
- AbbVie
- Brief Summary
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss. Treatments are available but do not work the same for all patients or may stop working over time. This study will evaluate the effectiveness and adverse events of targeted therapies (TaTs) for adult participants with moderate to severe CD.
The medicines assessed in this study are risankizumab, ABBV-382 and lutikizumab. When participants join the study, they will be randomized into available study treatment groups. Adult participants with CD will be enrolled. Around 500 participants will be enrolled in the study at approximately 300 sites worldwide.
Risankizumab and ABBV-382 are given as an injection under the skin or as an infusion into the vein. Lutikizumab is given as an injection under the skin. Each group includes a 12-week induction period, a 12-week maintenance period, and an optional long-term extension period where medication will be given after the maintenance period.
There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, endoscopies, checking for side effects and completing questionnaires and a daily diary.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 500
- Participants' body weight must be ≥ 40 kg at Baseline.
- Confirmed diagnosis of CD for at least 3 months prior to Baseline. Documentation of biopsy results consistent with the diagnosis of CD as assessed by the Investigator must be available.
- CDAI ≥ 220 at Baseline.
- Endoscopic evidence of mucosal inflammation as documented by an SES-CD of ≥ 6 for ileocolonic or colonic disease or SES-CD of ≥ 4 for isolated ileal disease. All eligible scores exclude the presence of narrowing component and are determined by a reader.
- Participants must demonstrate intolerance or inadequate response to TaTs including biologics
- Participant who demonstrated intolerance to p19 inhibitors, including risankizumab.
- Participant who received any investigational TaT (or TaT that becomes approved during the conduct of the study) within 30 days or 5 half-lives prior to Baseline, whichever is longer. Note: If there is documentation of an undetectable (or below the lower limit of quantification/quantitation) drug level measured by a commercially available assay for any of the approved biologics above, there is no minimum washout prior to Baseline.
- Participant who have any of the following: Current diagnosis of UC or indeterminate colitis. Currently known complications of CD such as: Current ostomy or ileoanal pouch; Current short gut or short bowel syndrome; Surgical bowel resection within the past 3 months prior to Baseline.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Monotherapy: Risankizumab Risankizumab Participants will receive Risankizumab Dose A as IV infusion and Risankizumab Dose B as SC injection. Monotherapy: Lutikizumab Lutikizumab Participants will receive Lutikizumab Dose A, Dose B and Dose C as SC injection. Long-Term Extension: Risankizumab Monotherapy Risankizumab Participants will receive Risankizumab Dose A as IV infusion and/or Risankizumab Dose B as SC injection for up to 72 weeks. Combination Therapy: Risankizumab and ABBV-382 Risankizumab Participants will receive Risankizumab Dose A as IV infusion and Risankizumab Dose C as SC injection; and ABBV-382 Dose A as IV infusion and ABBV-382 Dose B as SC injection. Monotherapy: ABBV-382 ABBV-382 Participants will receive ABBV-382 Dose A as IV infusion and ABBV-382 Dose B as SC injection. Combination Therapy: Risankizumab and ABBV-382 ABBV-382 Participants will receive Risankizumab Dose A as IV infusion and Risankizumab Dose C as SC injection; and ABBV-382 Dose A as IV infusion and ABBV-382 Dose B as SC injection. Combination Therapy: Risankizumab and Lutikizumab Risankizumab Participants will receive Risankizumab Dose A as IV infusion and Risankizumab Dose C as SC injection; and Lutikizumab Dose A, Dose B and Dose C as SC injection. Combination Therapy: Risankizumab and Lutikizumab Lutikizumab Participants will receive Risankizumab Dose A as IV infusion and Risankizumab Dose C as SC injection; and Lutikizumab Dose A, Dose B and Dose C as SC injection.
- Primary Outcome Measures
Name Time Method Percentage of Participants who Achieve Endoscopic Remission Week 12 The Simple Endoscopic Score for Crohn's Disease (SES-CD) assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic Remission is defined as SES-CD ≤ 4 and no sub score greater than 1 in any individual variable, as scored by a central reader.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With Clinical Remission Per Crohn's Disease Activity Index (CDAI) Week 12 The CDAI consists of 8 components; 7 are based on participant diary entries, participant interviews, physical examinations, measurement of body weight and height and 1 is based on laboratory analysis. CDAI clinical remission of Crohn's disease is defined as CDAI \< 150
Percentage of Participants who Achieve Endoscopic Response Week 12 The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic Response is defined as a decrease in SES-CD ≥ 50% from Baseline, as scored by central reader.
Percentage of Participants With Clinical Remission Per Stool Frequency/Abdominal Pain Score (SF/APS) Week 12 SF/APS clinical remission is defined as the average daily SF ≤ 2.8 and not worse than Baseline AND average daily AP score ≤ 1 and not worse than Baseline.
Trial Locations
- Locations (208)
Digestive Health Specialists /ID# 266216
🇺🇸Dothan, Alabama, United States
Nature Coast Clinical Research - Inverness /ID# 265874
🇺🇸Inverness, Florida, United States
East View Medical Research /ID# 270377
🇺🇸Mobile, Alabama, United States
Southern California Res. Ctr /ID# 265549
🇺🇸Coronado, California, United States
UC San Diego Health System /ID# 265565
🇺🇸La Jolla, California, United States
uc davis medical center - patient support services building /ID# 265554
🇺🇸Sacramento, California, United States
Clinical Applications Laboratories - San Diego - 3rd Avenue /ID# 267391
🇺🇸San Diego, California, United States
Peak Gastroenterology Associates - Colorado Springs - North Cascade Avenue /ID# 265557
🇺🇸Colorado Springs, Colorado, United States
Atlantic Medical Research /ID# 266207
🇺🇸Margate, Florida, United States
A Plus Research /ID# 265878
🇺🇸Miami, Florida, United States
Sanchez Clinical Research /ID# 265887
🇺🇸Miami, Florida, United States
Danbury Hospital, Western Connecticut Health Network /ID# 265556
🇺🇸Danbury, Connecticut, United States
Yale University School of Medicine /ID# 266786
🇺🇸New Haven, Connecticut, United States
Advanced Research Institute, Inc /ID# 265548
🇺🇸New Port Richey, Florida, United States
Hillcrest Medical Research, LLC /ID# 267237
🇺🇸Orange City, Florida, United States
Endoscopic Research, Inc. /ID# 267211
🇺🇸Orlando, Florida, United States
AdventHealth Medical Group - Tampa - Bruce B Downs Boulevard /ID# 265538
🇺🇸Tampa, Florida, United States
Florida Medical Clinic - Zephyrhills /ID# 267392
🇺🇸Zephyrhills, Florida, United States
Gastroenterology Associates of Central Georgia /ID# 265547
🇺🇸Macon, Georgia, United States
Treasure Valley Medical Research /ID# 267114
🇺🇸Boise, Idaho, United States
OSF St. Francis Medical Center /ID# 266973
🇺🇸Peoria, Illinois, United States
Springfield Clinic Main Campus /ID# 267434
🇺🇸Springfield, Illinois, United States
University of Kentucky Chandler Medical Center /ID# 265564
🇺🇸Lexington, Kentucky, United States
Metropolitan Gastroenterology Group - Chevy Chase /ID# 265877
🇺🇸Chevy Chase, Maryland, United States
Lucida Clinical Trials /ID# 266548
🇺🇸New Bedford, Massachusetts, United States
GI Associates Research, LLC /ID# 267433
🇺🇸Columbia, Missouri, United States
BVL Clinical Research /ID# 265870
🇺🇸Liberty, Missouri, United States
Washington University School of Medicine - St. Louis /ID# 266938
🇺🇸Saint Louis, Missouri, United States
Vector Clinical Trials /ID# 265561
🇺🇸Las Vegas, Nevada, United States
NYU Langone Long Island Clinical Research Association /ID# 265566
🇺🇸Great Neck, New York, United States
Icahn School of Medicine at Mount Sinai /ID# 266857
🇺🇸New York, New York, United States
Lenox Hill Hospital /ID# 265527
🇺🇸New York, New York, United States
Care Access - Yonkers /ID# 266781
🇺🇸Yonkers, New York, United States
Digestive Health Partners - Biltmore Office /ID# 265539
🇺🇸Asheville, North Carolina, United States
Velocity Clinical Research - Durham /ID# 267712
🇺🇸Durham, North Carolina, United States
University of Cincinnati /ID# 265589
🇺🇸Cincinnati, Ohio, United States
The Ohio State University /ID# 265577
🇺🇸Columbus, Ohio, United States
Digestive Disease Specialists - Oklahoma /ID# 265901
🇺🇸Oklahoma City, Oklahoma, United States
Penn State Health Milton South Hershey Medical Center /ID# 267126
🇺🇸Hershey, Pennsylvania, United States
University of Pennsylvania /ID# 265904
🇺🇸Philadelphia, Pennsylvania, United States
Gastroenterology Associates of Orangeburg /ID# 267548
🇺🇸Orangeburg, South Carolina, United States
GI associates of Northeast Tennessee /ID# 265567
🇺🇸Johnson City, Tennessee, United States
Gi Alliance - Cedar Park /ID# 268153
🇺🇸Cedar Park, Texas, United States
Proactive Clinical Research /ID# 267305
🇺🇸El Paso, Texas, United States
Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 266935
🇺🇸Garland, Texas, United States
Houston Methodist Hospital /ID# 265533
🇺🇸Houston, Texas, United States
Caprock Gastro Research - Lubbock - 80th Street /ID# 265541
🇺🇸Lubbock, Texas, United States
GI Alliance: Mansfield /ID# 266947
🇺🇸Mansfield, Texas, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 265899
🇺🇸San Antonio, Texas, United States
Sun Research Institute /ID# 266723
🇺🇸San Antonio, Texas, United States
Texas Digestive Disease Consultants - Southlake /ID# 265576
🇺🇸Southlake, Texas, United States
Tyler Research Institute, LLC /ID# 265545
🇺🇸Tyler, Texas, United States
Care Access - Ogden /ID# 266428
🇺🇸Ogden, Utah, United States
Care Access - Salt Lake City /ID# 266785
🇺🇸Salt Lake City, Utah, United States
Washington Gastroenterology - Tacoma /ID# 267302
🇺🇸Tacoma, Washington, United States
Klinikum Wels-Grieskirchen GmbH /ID# 266035
🇦🇹Wels, Oberoesterreich, Austria
Medizinische Universitaet Innsbruck /ID# 265930
🇦🇹Innsbruck, Tirol, Austria
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 265929
🇦🇹Linz, Austria
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 265928
🇦🇹Salzburg, Austria
Medizinische Universitaet Wien /ID# 265926
🇦🇹Wien, Austria
Imelda Ziekenhuis /ID# 265995
🇧🇪Bonheiden, Antwerpen, Belgium
Universite Libre de Bruxelles - Hopital Erasme /ID# 265993
🇧🇪Anderlecht, Bruxelles-Capitale, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 265522
🇧🇪Liege, Belgium
CHU Saint-Pierre /ID# 266431
🇧🇪Brussels, Bruxelles-Capitale, Belgium
UZ Leuven /ID# 265519
🇧🇪Leuven, Vlaams-Brabant, Belgium
Hospital Tsaritsa Yoanna /ID# 266235
🇧🇬Sofiya, Sofia, Bulgaria
Medical Center - Doverie /ID# 267050
🇧🇬Sofiya, Sofia, Bulgaria
ACIBADEM City Clinic Diagnostic-Consultative Center /ID# 266239
🇧🇬Sofiya, Sofia, Bulgaria
Cliniques Universitaires UCL Saint-Luc /ID# 265521
🇧🇪Bruxelles, Bruxelles-Capitale, Belgium
AZ Groeninge /ID# 265544
🇧🇪Kortrijk, West-Vlaanderen, Belgium
CHU de Liège /ID# 265542
🇧🇪Liège, Liege, Belgium
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 265517
🇧🇪Yvoir, Namur, Belgium
Umbal Kaspela /ID# 266234
🇧🇬Plovdiv, Bulgaria
2nd Mhat /ID# 266238
🇧🇬Sofia, Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD /ID# 267437
🇧🇬Sofia, Bulgaria
Military Medical Academy Multiprofile Hospital /ID# 267051
🇧🇬Sofia, Bulgaria
Multiprofile Hospital for Active Treatment Sveta Marina /ID# 266237
🇧🇬Varna, Bulgaria
University of Calgary /ID# 265524
🇨🇦Calgary, Alberta, Canada
Gastroenterology and Internal Medicine Research Institute /ID# 265610
🇨🇦Edmonton, Alberta, Canada
London Health Sciences Centre - University Hospital /ID# 267298
🇨🇦London, Ontario, Canada
Toronto Digestive Disease Associates /ID# 267358
🇨🇦Vaughan, Ontario, Canada
Diex Research - Quebec /ID# 265611
🇨🇦Quebec, Canada
Poliklinika Solmed /ID# 265509
🇭🇷Zagreb, Grad Zagreb, Croatia
Poliklinika Borzan d.o.o. /ID# 265503
🇭🇷Osijek, Osjecko-baranjska Zupanija, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 265511
🇭🇷Split, Splitsko-dalmatinska Zupanija, Croatia
Specijalna bolnica Medico Rijeka /ID# 265504
🇭🇷Rijeka, Croatia
Hepato-Gastroenterologie HK /ID# 265387
🇨🇿Hradec Králové, Hradec Kralove, Czechia
SurGal Clinic /ID# 265388
🇨🇿Brno, Jihomoravsky Kraj, Czechia
Iscare Klinické Centrum /ID# 265407
🇨🇿Prague, Praha 9, Czechia
East Tallinn Central Hospital /ID# 267658
🇪🇪Tallinn, Harjumaa, Estonia
Medicum /ID# 268304
🇪🇪Tallinn, Harjumaa, Estonia
Tartu University Hospital /ID# 267656
🇪🇪Tartu, Estonia
Chu de Nice-Hopital L'Archet Ii /Id# 267478
🇫🇷Nice, Alpes-Maritimes, France
Centre Hospitalier Universitaire de Bordeaux /ID# 265721
🇫🇷Pessac CEDEX, Gironde, France
CHU de Toulouse - Hôpital Rangueil /ID# 267479
🇫🇷Toulouse CEDEX 9, Haute-Garonne, France
CHU de Montpellier - Hopital Saint Eloi /ID# 265718
🇫🇷Montpellier, Herault, France
Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 265340
🇫🇷St-Priest-en-Jarez, Loire, France
CHRU de Nancy-Hopital Brabois Adultes /ID# 265703
🇫🇷Vandoeuvre les Nancy, Lorraine, France
Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 266851
🇫🇷Pierre Benite, Rhone, France
Clinique Jules Verne /ID# 267480
🇫🇷Nantes, France
Hôpital Saint Antoine /ID# 265725
🇫🇷Paris, France
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou /ID# 266848
🇫🇷Rennes, France
Universitaetsklinikum Freiburg /ID# 265755
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
Universitaetsmedizin Mannheim /ID# 266961
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Universitaetsklinikum Ulm /ID# 266962
🇩🇪Ulm, Baden-Wuerttemberg, Germany
Universitaetsklinikum Erlangen /ID# 265927
🇩🇪Erlangen, Bayern, Germany
Markus Krankenhaus /ID# 265938
🇩🇪Frankfurt am Main, Hessen, Germany
Klinikum Lueneburg /ID# 266886
🇩🇪Lueneburg, Niedersachsen, Germany
St. Marien- und St. Annastiftskrankenhaus /ID# 265912
🇩🇪Ludwigshafen am Rhein, Rheinland-Pfalz, Germany
Universitaetsklinikum des Saarlandes /ID# 265753
🇩🇪Homburg, Saarland, Germany
Studiengesellschaft BSF Unternehmergesellschaft /ID# 265751
🇩🇪Halle (Saale), Sachsen-Anhalt, Germany
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 265931
🇩🇪Dresden, Sachsen, Germany
Eugastro /ID# 266826
🇩🇪Leipzig, Sachsen, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Kiel /ID# 265738
🇩🇪Kiel, Schleswig-Holstein, Germany
Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 267254
🇩🇪Lübeck, Schleswig-Holstein, Germany
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 265752
🇩🇪Berlin, Germany
DRK Kliniken Berlin - Westend /ID# 265925
🇩🇪Berlin, Germany
Krankenhaus Waldfriede /ID# 266676
🇩🇪Berlin, Germany
Clinfan /ID# 267385
🇭🇺Szekszárd, Tolna, Hungary
Synexus Hungary Clinical Research Centre - Budapest /ID# 267384
🇭🇺Budapest, Hungary
Semmelweis Egyetem /ID# 267064
🇭🇺Budapest, Hungary
Semmelweis Egyetem /ID# 267068
🇭🇺Budapest, Hungary
Szegedi Tudományegyetem /ID# 267386
🇭🇺Szeged, Hungary
Portiuncula University Hospital /ID# 267771
🇮🇪Ballinasloe, Galway, Ireland
Our Lady of Lourdes Hospital - Drogheda /ID# 267768
🇮🇪Drogheda, Louth, Ireland
Midland Regional Hospital Mullingar /ID# 267769
🇮🇪Mullingar, Westmeath, Ireland
St. Vincent's University Hospital /ID# 267766
🇮🇪Dublin, Ireland
Beaumont Hospital /ID# 267770
🇮🇪Dublin, Ireland
Connolly Hospital /ID# 268021
🇮🇪Dublin, Ireland
Rambam Health Care Campus /ID# 267641
🇮🇱Haifa, H_efa, Israel
Edith Wolfson Medical Center /ID# 267640
🇮🇱Holon, HaMerkaz, Israel
Soroka Medical Center /ID# 267235
🇮🇱Be'er Sheva, HaDarom, Israel
Tel Aviv Sourasky Medical Center /ID# 267307
🇮🇱Tel Aviv, Tel-Aviv, Israel
Azienda Ospedaliero Universitaria di Cagliari - P.O. Duilio Casula /ID# 267287
🇮🇹Monserrato, Cagliari, Italy
IRCCS Ospedale San Raffaele /ID# 265951
🇮🇹Milan, Milano, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 265935
🇮🇹Rome, Roma, Italy
Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 267143
🇮🇹San Giovanni Rotondo, Foggia, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 265940
🇮🇹Rome, Roma, Italy
A.O. Ordine Mauriziano di Torino /ID# 267144
🇮🇹Turin, Torino, Italy
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 265942
🇮🇹Negrar, Verona, Italy
Inje University Haeundae Paik Hospital /ID# 266380
🇰🇷Busan, Busan Gwang Yeogsi, Korea, Republic of
The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 265488
🇰🇷Daejeon, Daejeon Gwang Yeogsi, Korea, Republic of
IRCCS Istituto Clinico Humanitas /ID# 265946
🇮🇹Rozzano, Lombardia, Italy
Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 267722
🇮🇹Catanzaro, Italy
Azienda Ospedaliera Universitaria Gaetano Martino /ID# 267145
🇮🇹Messina, Italy
Dong-A University Medical Center /ID# 266709
🇰🇷Busan, Busan Gwang Yeogsi, Korea, Republic of
Chungang University Hospital /ID# 266427
🇰🇷Dongjak-gu, Seoul Teugbyeolsi, Korea, Republic of
Samsung Medical Center /ID# 265489
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Kyungpook National University Chilgok Hospital /ID# 265487
🇰🇷Daegu, Korea, Republic of
Liepaja Regional Hospital /ID# 267703
🇱🇻Liepaja, Latvia
Pauls Stradins Clinical University Hospital /ID# 267705
🇱🇻Riga, Latvia
Digestive Diseases Center GASTRO /ID# 267707
🇱🇻Riga, Latvia
Hospital of Lithuanian University of Health Sciences Kaunas /ID# 267695
🇱🇹Kaunas, Lithuania
Panevezys Republican Hospital /ID# 267709
🇱🇹Panevezys, Lithuania
Vilnius University Hospital Santaros Klinikos /ID# 267711
🇱🇹Vilnius, Lithuania
Elisabeth TweeSteden Ziekenhuis /ID# 265729
🇳🇱Tilburg, Noord-Brabant, Netherlands
Amsterdam UMC, locatie AMC /ID# 268321
🇳🇱Amsterdam, Noord-Holland, Netherlands
Universitair Medisch Centrum Utrecht /ID# 265731
🇳🇱Utrecht, Netherlands
Helse More- og Romsdal HF, Alesund sjukehus /ID# 267632
🇳🇴Alesund, More Og Romsdal, Norway
Oslo Universitetssykehus Ulleval /ID# 267630
🇳🇴Oslo, Norway
NZOZ Centrum Medyczne KERmed /ID# 266766
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Gastromed Sp. z o.o /ID# 266765
🇵🇱Torun, Kujawsko-pomorskie, Poland
Malopolskie Centrum Kliniczne /ID# 265943
🇵🇱Krakow, Malopolskie, Poland
Medical Network Sp.z.o.o. WIP Warsaw IBD Point Profesor Kierkus /ID# 266764
🇵🇱Warsaw, Mazowieckie, Poland
Bodyclinic Sp. z o.o. sp.k. /ID# 265945
🇵🇱Warszawa, Mazowieckie, Poland
Endoskopia Sp. z.o.o. /ID# 265934
🇵🇱Sopot, Pomorskie, Poland
H-T Centrum Medyczne Endoterapia /ID# 265937
🇵🇱Tychy, Slaskie, Poland
Polimedica PTG Kielce /ID# 267066
🇵🇱Kielce, Swietokrzyskie, Poland
Unidade Local de Saude do Alto Ave, EPE /ID# 265892
🇵🇹Guimaraes, Braga, Portugal
2CA-Braga, Hospital de Braga /ID# 265894
🇵🇹Braga, Portugal
Unidade Local de Saude de Coimbra, EPE /ID# 267240
🇵🇹Coimbra, Portugal
Unidade Local de Saude de Lisboa Ocidental, EPE /ID# 267242
🇵🇹Lisboa, Portugal
Unidade Local de Saude de Santa Maria, EPE /ID# 266113
🇵🇹Lisboa, Portugal
Unidade Local de Saude do Alto Minho, EPE - Hospital de Santa Luzia /ID# 265885
🇵🇹Viana Do Castelo, Portugal
Memorial Healthcare International S.R.L. /Id# 267328
🇷🇴Bucharest, Bucuresti, Romania
Clinica Gastro Med SRL /ID# 267204
🇷🇴Cluj-Napoca, Cluj, Romania
OncoHelp Association /ID# 267203
🇷🇴Timișoara, Timis, Romania
Spitalul Clinic Colentina /ID# 267208
🇷🇴Bucharest, Romania
Clinical Hospital Center Zvezdara /ID# 265605
🇷🇸Belgrade, Beograd, Serbia
University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje" /ID# 265607
🇷🇸Belgrade, Beograd, Serbia
Clinical Hospital Center - Bežanijska Kosa /ID# 265604
🇷🇸Belgrade, Beograd, Serbia
Leskovac General Hospital /ID# 265606
🇷🇸Leskovac, Jablanicki Okrug, Serbia
General Hospital Djordje Joanovic /ID# 266040
🇷🇸Zrenjanin, Vojvodina, Serbia
University Clinical Center Vojvodina /ID# 265603
🇷🇸Novi Sad, Serbia
Gastroenterology and Liver Specialist Clinic /ID# 268354
🇸🇬Singapore, Central Singapore, Singapore
Gleneagles Hospital /ID# 268385
🇸🇬Singapore, Central Singapore, Singapore
National University Hospital /ID# 268128
🇸🇬Singapore, Singapore
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 266064
🇸🇰Banska Bystrica, Banskobystricky Kraj, Slovakia
KM Management, spol. s.r.o. /ID# 266070
🇸🇰Nitra, Nitriansky Kraj, Slovakia
Gastro I., s.r.o. /ID# 267159
🇸🇰Prešov, Presovsky Kraj, Slovakia
ENDOMED s.r.o /ID# 266068
🇸🇰Košice, Slovakia
General Hospital Celje /ID# 267699
🇸🇮Celje, Slovenia
University Medical Centre Ljubljana /ID# 267697
🇸🇮Ljubljana, Slovenia
Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 266902
🇪🇸Santiago de Compostela, A Coruna, Spain
Hospital Universitario Virgen Macarena /ID# 266648
🇪🇸Seville, Sevilla, Spain
Hospital Universitario Virgen del Rocio /ID# 266727
🇪🇸Seville, Sevilla, Spain
Hospital Clinic de Barcelona /ID# 265415
🇪🇸Barcelona, Spain
Hospital Universitario 12 de Octubre /ID# 265444
🇪🇸Madrid, Spain
Hospital Universitario La Paz /ID# 265412
🇪🇸Madrid, Spain
Gartnavel General Hospital /ID# 266407
🇬🇧Glasgow, Glasgow City, United Kingdom
Hospital Alvaro Cunqueiro /ID# 266647
🇪🇸Pontevedra, Spain
Hospital Universitari i Politècnic La Fe /ID# 265478
🇪🇸Valencia, Spain
Royal Free Hospital /ID# 268065
🇬🇧London, Greater London, United Kingdom
The John Radcliffe Hospital /ID# 266334
🇬🇧Oxford, Oxfordshire, United Kingdom
Intesto /ID# 265728
🇨🇭Bern, Switzerland
The Royal Wolverhampton NHS Trust /ID# 268158
🇬🇧Guildford, Surrey, United Kingdom
Barts Health NHS Trust /ID# 266410
🇬🇧London, United Kingdom
Royal Victoria Infirmary /ID# 268064
🇬🇧Newcastle upon Tyne, United Kingdom