Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects

Not Applicable

• Conditions: Sleep Apnea Syndrome

• Registration Number: NCT00746928
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.

Precisely, the study was designed to :

Set up a new model of Chronic Intermittent Hypoxia (CIH) applied to healthy human. This CIH is mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome.

Evaluate the cardiovascular effect of CIH. Neuronal and humoral sympathetic control, blood pressure control, vascular resistance.

Evaluate the Sleep quality, the ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex).

Investigates the biological aspects of CIH exposure.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09
• Primary Completion: 2007-07
• Status Verified: 2008-09
• Study First Submitted: 2008-09-01
• Study First Submitted QC: 2008-09-03
• Last Update Submitted: 2008-09-03
• Study First Posted: 2008-09-04
• Last Update Posted: 2008-09-04
• Study Completion: 2008-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy subjects

Exclusion Criteria

• Any history or significant medical condition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Blood Pressure	Two Weeks

Secondary Outcome Measures

Name	Time	Method
The ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex)	two weeks
Sleep quality	Two Weeks
Neuronal and humoral sympathetic control and vascular resistance.	Two weeks

Trial Locations

Locations (1)

Pulmonary Function and sleep Lab, CHU Grenoble; 🇫🇷 Grenoble, France