NCT00746928UnknownNot Applicable
Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
University Hospital, Grenoble2 sites in 1 country12 target enrollmentStarted: September 1, 2005Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 12
- Locations
- 2
- Primary Endpoint
- Blood Pressure
Study Overview
Brief Summary
The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.
Precisely, the study was designed to :
Set up a new model of Chronic Intermittent Hypoxia (CIH) applied to healthy human. This CIH is mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome.
Evaluate the cardiovascular effect of CIH. Neuronal and humoral sympathetic control, blood pressure control, vascular resistance.
Evaluate the Sleep quality, the ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex).
Investigates the biological aspects of CIH exposure.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy subjects
Exclusion Criteria
- •Any history or significant medical condition
Outcomes
Primary Outcomes
Blood Pressure
Time Frame: Two Weeks
Secondary Outcomes
- The ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex)(two weeks)
- Sleep quality(Two Weeks)
- Neuronal and humoral sympathetic control and vascular resistance.(Two weeks)
Investigators
Study Sites (2)
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