Comparison of percutaneous hyaluronidase injection, percutaneous laser disc decompression (PLDD) and percutaneous ozone injection in radiculopathy of patients with herniated lumbar disc.

Phase 3

Recruiting

Conditions: umbosacral radiculopathy.
Radiculopathy, lumbar region
M54.16

Registration Number: IRCT20130523013442N36

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

Patients with lumbar radiculopathy whose duration of symptoms is between 6 weeks and 6 months and has not responded well to conservative treatment (NSAIDs, physiotherapy or epidural injection)
The minimum VAS score of all participants is considered 5.
In MRI, confirmed disc herniation in one level with grade 1A, 2A, 1B, 2B based on the Michigan State University (MSU) classification

Exclusion Criteria

Cauda equina syndrome
The presence of any defect in motor function.
Major neurological deficit
Allergy to bovine proteins in patient treated with hyaluronidase?
Pregnancy and breastfeeding
Spondylodiscitis
Spondylolisthesis
Spinal canal stenosis
more than 50% Reduction of disc height
Previous history of spine surgery

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of lumbar pain. Timepoint: At the beginning of the study (before intervention) and 4 weeks, 12 weeks and 24 weeks after the intervention. Method of measurement: Visual analogue scale (VAS).;Evaluation of pain, function and return to activity. Timepoint: At the beginning of the study (before intervention) and 4 weeks, 12 weeks and 24 weeks after the intervention. Method of measurement: Using the Modified Macnab questionnaire.;Assessment of the patient's disability in daily living. Timepoint: At the beginning of the study (before intervention) and 4 weeks, 12 weeks and 24 weeks after the intervention. Method of measurement: Using the Oswestry low back disability (ODI) questionnaire.

Secondary Outcome Measures