Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 292
- 试验地点
- 1
- 主要终点
- Birth Weight at Delivery
研究概览
简要总结
Alkaline phosphatase is known to be produced by syncytiotrophoblasts in the placenta and its levels are normally increased in pregnancy. Therefore, it would be reasonable to hypothesize that alkaline phosphatase would be low to low normal in cases of low birth weight / intrauterine growth restriction (IUGR)/ placental insufficiency.
详细描述
The purpose of this study will be to determine if alkaline phosphatase can be used as a predictor for suboptimal fetal growth, placental insufficiency and low birth weight (birth weight less than 2500 grams). It will also help determine if alkaline phosphatase can be used as a screening tool for low birth weight/IUGR at the time of the 24 to 28 week labs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients enrolled between 24w0d and 28w6d weeks gestational age will be included. The blood specimen of the patients enrolled will be held until delivery.
排除标准
- •Multiple gestations
- •Known congenital malformations (any, except Pyelectasis)
- •Chronic hypertension
- •Inflammatory bowel disease (IBD)
- •Gall bladder disease
- •Active bone disease (ie, skeletal dysplasia, healing fracture)
- •Active liver disease (ie, hepatitis, cholestasis, cholelithiasis (gallstones))
- •Pre-existing type 1 and 2 Diabetes
- •Early-onset IUGR
结局指标
主要结局
Birth Weight at Delivery
时间窗: At Delivery
Birth Weight at Delivery
次要结局
未报告次要终点