The Genetic Study of Longitudinal Brain Function Among Schizophrenic Patients With Family History
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Schizophrenia
- 发起方
- Taichung Veterans General Hospital
- 入组人数
- 600
- 试验地点
- 1
- 最后更新
- 16年前
概览
简要总结
The goal of this research is to find out possible susceptible gene(s) in schizophrenic patients with family history and 5-year period functional changes of brain among the members of family, in order to further analysis factors and their interactions.
详细描述
Schizophrenia is a serious mental disease, highly family inheritable inclination. By means of traditional psychiatry diagnosis, genetics and long term brain change researches will help to unveil the secret of schizophrenia and other factors. The advantage of comparative gene hybridization is that chromosome copy number alterations can be detected; this technique has been widely applied in many researches, such as cancer, mental retardation screening and autism. As we known, we are the first one use this technique in chromosome abnormality research for family history schizophrenic patient, this study also is the first one to track the relationship of long term brain function alteration and chromosome abnormality in Taiwan.
研究者
入排标准
入选标准
- •1.Psychiatry doctor diagnosed who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for schizophrenia or schizoaffective disorder, family history, age older than 15 will be recruited for participation in this study. Participants agree and sign informed consent forms will eligible to participate this experiment.
- •2.10-20c.c blood will be drawn from the participants. 3.Participants need to understand procedures and assays of this experiment. 4.At least one psychiatry doctor interview needed, participants and their family voluntarily join this interview, approximately 30-45min.
排除标准
- •Participant can not understand procedures and assays of this experiment.
- •Participant has another major mental disease other than the inclusion criteria.
- •Participant has material abuse history, it could seriously influence diagnosis.
- •Participant has combination diseases, it could seriously influence diagnosis.
- •Psychopathy or psychosis can not be categorized in defined group.
- •Other considerations:
- •Participants, age fewer than 20 needs to their deputy guardians (parents) and their own consent altogether.
- •Participants who are inability needs to their deputy guardians (parents) and their own consent altogether.
结局指标
主要结局
未指定