Liver Transplantation for Unresectable GIST Liver Metastases

Not Applicable

Not yet recruiting

• Conditions: Gastrointestinal Stromal Tumors; Gastrointestinal Stromal Tumor of Rectum; Gastrointestinal Stromal Tumor, Unspecified Site; Gastrointestinal Stromal Tumor of Small Intestine (Disorder); Metastatic Liver Cancer; Liver Mass; Gastrointestinal Stromal Tumor of Other Sites; Gastrointestinal Stromal Tumor by AJCC V8 Stage; Gastrointestinal Stromal Tumor, Malignant; Gastrointestinal Stromal Tumor of Large Intestine (Disorder)
• Interventions: Procedure: Liver Transplantation

• Registration Number: NCT04825470
• Lead Sponsor: Hospital Universitario Virgen de la Arrixaca

Brief Summary

Liver Transplantation for Unresectable GIST Liver Metastases

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-03-23
• Study First Submitted QC: 2021-03-29
• Study First Posted: 2021-04-01
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-24
• Last Update Posted: 2022-03-11
• Study Start: 2022-05
• Primary Completion: 2023-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• GIST diagnosis (c-Kit, CD34, DOG-1)
• Imatinib-sensitive mutation
• Non-resectable liver metastases
• Abscence of extrahepatic disease
• Period greater than two years between primary tumor and metastases diagnosis

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Liver Transplantation	Liver Transplantation	-

Primary Outcome Measures

Name	Time	Method
Overall Survival	Through study completion, an average of 2 years	Survival
Graft Survival	Through study completion, an average of 2 years	Liver graft Survival

Secondary Outcome Measures

Name	Time	Method
Relapse free survival	Through study completion, an average of 2 years
Disease free survival	Through study completion, an average of 2 years

Trial Locations

Locations (1)

Felipe Alconchel; 🇪🇸 Murcia, Spain