EUCTR2004-004741-17-DK进行中（未招募）不适用
SPC2996 in Chronic Lymphocytic LeukaemiaAn open-labelled, international multicenter dose escalating, phase I/II study of SPC2996, an LNA antisense molecule against Bcl-2, in patients with relapsed or refractory Chronic Lymphocytic Leukaemia - SPC2996 in Chronic Lymphocytic Leukaemia
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 42
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •1)Relapsed or refractory CLL/SLLrequiring therapy
- •2)Circulating lymphocytes > 5 x 109/L at screening blood sample
- •3)Circulating lymphocytes expressing the following phenotype at screening blood sample: CD5+CD20+CD23+
- •4)(This inclusion criterion has been deleted according to Intl. Protocol Amendment 2, dated 25 January 2006)
- •5)Age = 18 years
- •6)Following receipt of oral and written information about the study the patient must give a signed consent before any study related activity is carried out.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •1)Previous treatment with rituximab within 6 months prior to Visit 1
- •2)Previous treatment with alemtuzumab within 6 months prior to Visit 1
- •3)Previous autologous stem cell transplantation within 6 months prior to Visit 1
- •4)Previous allogeneic stem cell transplantation
- •5)Received any of the following treatments within 4 weeks prior to Visit 1:
- •Anti-cancer therapy
- •Glucocorticoids unless = 10 mg prednisolon /day for other indications than CLL
- •Radiotherapy
- •6)Known or suspected transformation of CLL (e.g. B-symptoms, fast growing tumour or increasing LDH level)
研究者
相似试验
进行中（未招募）
1 期
SPC2996 in Chronic Lymphocytic LeukaemiaAn open-labelled, international multicenter dose escalating, phase I/II study of SPC2996, an LNA antisense molecule against Bcl-2, in patients with relapsed or refractory Chronic Lymphocytic Leukaemia - SPC2996 in Chronic Lymphocytic LeukaemiaChronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in adults in the US and most of Western Europe. The incidence is 8100 to 12500 new cases in the US per year. CLL is a relatively indolent disease mainly of the elderly. CLL is a disease of B cell origin grouped together with small lymphocytic lymphoma (SLL) in the WHO classification system. CLL and SLL together correspond to around 20 % of all NHL cases.EUCTR2004-004741-17-GBSantaris Pharma42
招募中
3 期
A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination with Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)Chronic Lymphocytic Leukemia2024-512147-23-00AbbVie Deutschland GmbH & Co. KG170
进行中（未招募）
2 期
PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaLeukemia, LymphocytycCLL (Chronic Lymphocytic Leukemia)SLL (Small Lymphocytic Lymphoma)LeukemiaNCT01500733National Heart, Lung, and Blood Institute (NHLBI)86
招募中
2 期
Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)Chronic Lymphocytic Leukemia (CLL)NCT04895436AbbVie75
进行中（未招募）
不适用
A Study to Assess Change in Functioning and Health Related Quality of Life in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Treatments in Routine Clinical Practice in SpainChronic Lymphocytic LeukemiaNCT06125795AbbVie146