Disease mechanisms and markers for non-alcoholic steatohepatitis in a population with non-alcoholic fatty liver disaese: a prospective cohort study with biobank - Prospective cohort and biobank of nonalcoholic fatty liver disease patients

niversiteit Maastricht0 个研究点目标入组 500 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•- NAFLD diagnosis based on evidence of hepatic steatosis, either by imaging (any form) or by histology
•- BMI >= 25
•- Between 18 - 65 years of age

•- Incompetent to understand and/or sign the informed consent.
•- Causes for secondary hepatic fat accumulation such as significant alcohol consumption, medications, Wilson*s disease, viral infections, starvation or parenteral nutrition, among others, and conditions associated with microvesicular steatosis (excluding hemochromatosis)
•- Ethanol consumption exceeding more than 14 standard beverages per week for males and more than 7 standard beverages per week for female.
•- Unwilling to collect biosamples
•- Pregnancy and breastfeeding.
•- A history of bariatric surgery.
•- Diagnosis of liver cirrhosis and/or hepatocellular carcinoma.
•- Diagnosis of extrahepatic malignancies
•- Individuals about to undergo or recovering from a surgical or otherwise medical procedure that will interfere with data collection and analyses planned within the current cohort, will initially be excluded from participation, but are offered the opportunity to participate at a later moment in time (e.g., after 3 months are myocardial infarction patients are eligible for participation).

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