nderstanding B cell biology in auto-immune diseases. - Understanding B cell biology in auto-immune diseases.

eids Universitair Medisch Centrum0 个研究点目标入组 1,095 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•Inclusion criteria patients
•- Age 18 years or older (no minors or incapacitated subjects will be included
•in the study)
•- Ability to understand the patient information form and ability to provide
•written informed consent.
•- a definite diagnosis of rheumatoid arthritis, systemic lupus erythematodes,
•ANCA-associated vasculitis, or systemic sclerosis based on current
•classification criteria or
•- fulfilment of the current classification criteria for *clinically suspect
•arthralgia* in the concomitant presence of ACPA in serum.
•- Written informed consent
•Inclusion criteria healthy subjects:
•- Age 18 years or older (no minors or incapacitated subjects will be included
•in the study)
•- Ability to understand the patient information form and ability to provide
•written informed consent.
•- a self-reported absence of a definite diagnosis of rheumatoid arthritis,
•systemic lupus erythematosus, ANCA-associated vasculitis, or systemic sclerosis
•based on current classification criteria or of complaints compatible with the
•current classification criteria for *clinically suspect arthralgia*.

•Exclusion criteria patients
•- Individuals who fail to meet the inclusion criteria
•- Individuals for whom the treating physician considers that relevant safety
•issues apply (such as, for example, severe anemia) that preclude the provision
•of 50 ml of peripheral blood.
•- Individuals who have donated 50 ml of blood (or more) less than two weeks
•prior to the respective time-point for any reason (such as routine clinical
•care, participation in another study, blood donations for the blood bank, etc.)
•exclusion criteria healthy subjects:
•- Individuals who fail to meet the inclusion criteria
•- Individuals who have donated 50 ml of blood (or more) less than two weeks
•prior to the respective time-point for any reason (such as routine clinical
•care, participation in another study, blood donations for the blood bank, etc.)

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