A Prospective study on the Efficacy of an integrated intensive lifestyle intervention program on management of obesity and associated comorbidities in Indian population

The proposed study is a prospective, quasi-experimental, single-arm pre-post design that aims to assess the effect of an integrated intensive lifestyle intervention (ILI) in the management of obesity and associated comorbidities. The specific objectives of this study are 1) To assess the impact of an online intensive lifestyle intervention on weight loss, body mass index (BMI), and body composition (BC) parameters. 2) To assess the prevalence of comorbidities including prediabetes, T2D, dyslipidemia, hypertension, anxiety, depression, and stress. 3)To assess the effect of the intervention on improvements in comorbidities. 4)To assess the baseline characteristics of obese participants who attended an ILI-based management program. 5) To investigate the associations between clinical, anthropometric, biochemical, mental health, sleep quality, and physical activity outcomes in individuals with obesity. The targeted intervention will include dietary, exercise, psychological, and medical management. The mode of delivery of the intervention will be through online group sessions and individual counseling. The duration of the intervention will be one year. The data on sociodemographics will be collected at the time of enrollment. Data on anthropometric, body composition (measured by Karda scan and DXA),  biochemical parameters (e.g., Serum Lipids, Fasting, and post-prandial plasma glucose, creatinine/eGFR. LFT, RFT), and GPAQ (physical activity), will be collected at baseline and the end of the intervention (12 months). Meanwhile, data for the PHQ-9, GAD-7 (Depression and Anxiety), and PSQI (sleep quality index) scales will be collected at baseline and at the end of 6 months. To check the compliance adherence data will be collected from the patients.