Comparison of aggressive versus standard intravenous hydration for clinical improvement in mild acute pancreatitis patient: A randomized controlled trial

Department of medicine, Phramongkutklao hospital0 个研究点目标入组 44 人开始时间: 2021年2月23日最近更新: 2024年8月19日

适应症

试验速览

阶段: 3 期
状态: 已完成
发起方: Department of medicine, Phramongkutklao hospital
入组人数: 44

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

Aggressive intravenous hydration did not statistically significant improve the clinical outcome compared with standard intravenous hydration (45.45% vs 31.82%, respectively; p-value 0.353). However, sub-group analysis between obese and non-obese patient, aggressive intravenous hydration was a significant improve the clinical outcome within first 24 hours

研究设计

研究类型: Interventional

入排标准

年龄范围: 18 Years 至 80 Years（—）
性别: All

入选标准

•Patients aged >18 years who admitted to emergency department were diagnosed acute pancreatitis using Revised Atlanta classification defined by two of three following criteria: (1) epigastric abdominal pain, (2) elevated serum amylase and/or lipase greater than 3 times the upper limit of normal, (3) characteristic findings from abdominal imaging.

排除标准

•Exclusion criteria included advanced aged greater than 80 years old, New York Heart Association Class II or greater heart failure, active myocardial ischemia, cardiovascular intervention within previous 60 days, history of cirrhosis, renal insufficiency with creatinine clearance < 40 mL/min, chronic obstructive pulmonary disease with requirement home oxygen, patients with bowel ischemia or bowel perforation, hypercalcemia, clinical signs of volume overload, post-intervention pancreatitis and severe pancreatitis (PO2/FiO2 < 300, Systolic blood pressure < 90 mmHg, Serum creatinine > 2 mg/dl). Patients with history of metastasis malignancy, autoimmune disease, chronic infectious disease including human immunodeficiency virus or tuberculosis were excluded because of potential confounding related to inflammatory markers.

研究者

发起方

Department of medicine, Phramongkutklao hospital

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