Optimizing Strength Training in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- 6-minute walk test
研究概览
简要总结
The objective of the current study is to determine whether lifting lighter loads close to failure improves strength training adaptations and function in older adults. The main questions it aims to answer are:
- The effect of light loads on physical function
- The effect of light loads on muscle mass, power, and strength
Researchers will compare a light-load, high-repetition program to a standard strength training program. Participants will perform supervised strength training twice per week for 20 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
盲法说明
Statistician
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females aged 65 years and above
- •Inactive lifestyle (< 150 min per week of moderate intensity physical activity) and not regularly participating in a structured strength training program
- •Planning to reside in the area for the duration of the study
排除标准
- •Severe cardiac disease, including Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
- •Lung disease requiring either oral or injected steroids, or the use of supplemental oxygen
- •Short, portable mental status questionnaire with 3 or more errors
- •Severe arthritis (either osteoarthritis or rheumatoid arthritis)
- •Cancer requiring treatment in the past 1 year (melanomas excluded)
- •Development of chest pain or severe shortness of breath during the 6 min self-paced walk test
- •Parkinson's disease or other serious neurological disorders
- •Renal disease requiring dialysis
- •Current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder
- •Current consumption of more than 14 alcoholic drinks per week
- •Severe lower back or shoulder pain that may worsen with weightlifting exercises
- •Undergoing physical therapy involving the lower extremities
- •Living in nursing homes, assisted living facilities or other similar institutions
- •Currently enrolled in another randomized trial involving a pharmaceutical or lifestyle intervention
- •Weight change (intentional or not) over the last 6 months of > 5% of body weight, or plan to lose or gain weight during the study
- •Any other cardiovascular, pulmonary, orthopedic, neurologic, or other conditions that would preclude participation and successful completion of the protocol
- •Temporary Exclusion Criteria
- •A person meeting any of the following temporary exclusion criteria at the time of screening will not be enrolled but may be re-screened later.
- •Severe hypertension, e.g., SBP > 200 mm Hg, DBP > 110 mm Hg
- •Major surgery or fracture or hip/knee replacement within the last 6 months
- •Hospitalization within the last 6 months (excluding ER visits)
研究组 & 干预措施
Light Load, High Repetition (LLHR)
The LLHR group will perform a full-body routine with lighter weights, performing 16-20 repetitions per set, close to failure.
干预措施: Strength training (Behavioral)
Strength Training (ST)
The ST group will perform a full-body routine with higher weights, performing 8-12 repetitions per set, close to failure.
干预措施: Strength training (Behavioral)
结局指标
主要结局
6-minute walk test
时间窗: Baseline and week 21
Change in the total distance walked in 6 minutes. The 6-minute walk test is an objective, well-validated, and clinically meaningful measure of physical function in older adults.
次要结局
- Lean body mass (LBM)(Baseline and week 21)
- Exercise session attendance(From enrollment to the end of 20-week intervention period)
- Lower body maximal muscle strength(Baseline and week 21.)
- Lower body muscle power(Baseline and week 21)
- Self-reported physical function(Baseline and week 21)
- Get-up & go test(Baseline and week 21)
- 30-second chair stand test(Baseline and week 21)
- Number of participants with adverse events(From enrollment to the end of 20-week intervention period)
- Physical activity enjoyment scale (PACES)(Week 21)
- Exercise self-efficacy questionnaire(Week 21)
研究者
Anoop T Balachandran
Assistant Professor
Queens College, The City University of New York