临床试验/NCT01114581

NCT01114581已完成2 期

Evaluating the Effect of Mucinex 1200mg on Mucociliary and Cough Clearance During an Acute Respiratory Infection

Reckitt Benckiser LLC1 个研究点分布在 1 个国家目标入组 38 人开始时间: 2010年4月最近更新: 2018年9月19日

适应症

干预措施

试验速览

阶段: 2 期
状态: 已完成
发起方: Reckitt Benckiser LLC
入组人数: 38
试验地点: 1
主要终点: Percent of Inhaled Radioactive Tracer Particles Cleared From Lungs

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this research study is to explore the mechanism of action of Mucinex, an oral, over-the-counter, FDA approved expectorant in patients with acute respiratory tract infections.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Triple (Participant, Care Provider, Investigator)

入排标准

年龄范围: 18 Years 至 65 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Symptoms of cough, thickened mucus and chest congestion
•Able to produce sputum
•Non Smoker

排除标准

•Fever above 101°F
•Any chronic illness

研究组 & 干预措施

Guaifenesin

Active Comparator

Mucinex 1200mg (Guaifenesin)given as 2, 600mg tablets

干预措施: Mucinex (Drug)

Placebo

Placebo Comparator

Given as 2 tablets

干预措施: Placebo (Drug)

结局指标

主要结局

Percent of Inhaled Radioactive Tracer Particles Cleared From Lungs

时间窗: 3 hours following inhalation of radioactive tracer particles

Percentage of inhaled radioactive tracer (Ave180Clear)

次要结局

Guaifenesin AUC(0-3)(3 hours following dose administration)
Assess Sputum Properties (Objective Measures) and Symptoms (Subjective Measures) After Treatment With Mucinex or Placebo.(Within 10 days of developing symptoms associated with a respiratory tract infection)

研究者

发起方

Reckitt Benckiser LLC

申办方类型

Industry

责任方

Sponsor

研究点 (1)

Loading locations...

相似试验

已完成

不适用

Mucinex® for Treatment of Filamentary KeratitisFilamentary Keratitis

NCT02859246Massachusetts Eye and Ear Infirmary15

已完成

4 期

Phase 4 Study - Mucinex D as Adjunct TherapyRhinosinusitisAcute Respiratory InfectionBronchitis

NCT00441246Adams Respiratory Therapeutics600

已完成

不适用

Meu-cinn for Gastric Mucosal Health in Adults With Functional DyspepsiaFunctioanl Dyspepsia

NCT06630455Pusan National University Yangsan Hospital100

已完成

4 期

Safety and Efficacy Study of Guaifenesin and Pseudoephedrine for Symptomatic Therapy to Treat Acute RTIAcute Upper Respiratory Track Infection

NCT01202279Reckitt Benckiser Inc.1,179

已完成

1 期

Evaluating the Effect of Mucinex® 1200 mg on Mucociliary and Cough Clearance From the Human LungMucociliary Clearance

NCT00902707University of North Carolina, Chapel Hill12