Pilot Investigation of a Multinutrient Supplement on Skin Aging and Aging Metabolites in Healthy Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- Fold Change in Long Chain Fatty Acids
研究概览
简要总结
We are seeking healthy female volunteers to determine if multinutrient supplementation affects visible signs of skin aging as well as blood measurements of aging. We are seeking smokers and non-smokers.
详细描述
Skin antioxidant levels as well as blood metabolites may change as the human body ages1,2. Although the chronological aging process is unstoppable, the physical signs of aging, particularly characteristics of the skin, may be delayed through a variety of medical interventions such as topical medications or resurfacing lasers. It is not currently known whether skin carotenoid antioxidant levels correlate with skin aging characteristics, although studies with other antioxidants suggest this may be true 3. In addition, while selected blood metabolites correlate with changes in age2, we do not know if this correlates with skin changes. Our current study focuses on whether differences in skin carotenoid levels and blood metabolite levels correlate with skin aging characteristics in age-matched subjects. Furthermore, we will explore whether three months consumption with a commercial multi-nutrient formulation (LifePak Nano) affects metabolic markers of aging, skin aging characteristics including skin elasticity and transepidermal water loss. We will also examine whether smokers respond differently from nonsmokers in the above parameters after supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Fitzpatrick Skin type I or II
- •Nonpregnant Females, age 18-30 or 50-70
- •Body Mass Index Normal or Overweight
- •If age 18-30, must be non-smoker
- •Willing to fast for 8 hours prior to a blood draw;
排除标准
- •History of cosmetic surgery
- •Use of anti-aging medications within 3 months of enrollment
- •Use of over-the-counter anti-aging creams (not sunscreens) more than once per week within one month of enrollment
- •Use of dietary supplements including vitamins within one month of enrollment
- •Use of tanning beds or excessive UV exposure (greater than 2 hours per day) within one month of enrollment
- •Use of sunless tanners within one month of enrollment
- •Uncontrolled or ongoing serious medical condition
- •Participation in another clinical study involving use of an investigational drug or product
- •Medical condition which, at the discretion of the investigator, will have a significant impact on ability to judge participant's skin characteristics, including age.
研究组 & 干预措施
Nonsmoker
Nonsmokers Intervention: Dietary Supplement: LifePak Nano
干预措施: Dietary Supplement: LifePak Nano (Drug)
Smoker
Smoker arm Intervention: Dietary Supplement: LifePak Nano
干预措施: Dietary Supplement: LifePak Nano (Drug)
结局指标
主要结局
Fold Change in Long Chain Fatty Acids
时间窗: Baseline; Week 12
Peripheral blood long chain fatty acids were measured. Fold change of 1 = no difference; if metabolites decrease at week 12 from baseline, the fold change will be \<1.
Change in Fine Wrinkling
时间窗: Baseline; week 12
Assessed by 4 dermatologists blinded to chronological age and smoking status, on a 10-point Likert scale (min 1/max 10); lower scores indicate less wrinkling and higher scores indicate more wrinkling. Values are the average of scores given by the four raters. Change was calculated as the baseline value minus the week 12 value.
次要结局
未报告次要终点
研究者
Anne Chang
Professor
Stanford University