NL-OMON35765已完成不适用
The effects of immunostimulation with GM-CSF or IFN-γ on immunoparalysis following human endotoxemia. A parallel randomised double-blind placebo-controlled study - Effects of GMCSF/IFN-γ on immunoparalysis
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 18 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 18
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age >=18 and <=35
排除标准
- •- Use of any medication
- •- History of allergic reaction to GM-CSF/ IFN-γ.
- •- Smoking.
- •- Previous spontaneous vagal collapse.
- •- History, signs or symptoms of cardiovascular disease.
- •- (Family) history of myocardial infarction or stroke under the age of 65 years.
- •- Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a
- •complex bundle branch block.
- •- Hypertension (defined as RR systolic > 160 or RR diastolic > 90).
- •- Hypotension (defined as RR systolic < 100 or RR diastolic < 50).
- •- Renal impairment (defined as plasma creatinin >120 µmol/l).
- •- Liver enzyme abnormalities or positive hepatitis serology.
- •- Positive HIV serology or medical history of any other obvious disease associated with immune deficiency.
- •- Febrile illness during the week before the LPS challenge.
- •- Participation in a drug trial or donation of blood 3 months prior to the LPS challenge.
- •- Chronic hiccups (defined as hiccups longer than 15 minutes in the past 6 months)
- •- Pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including diabetes and auto-immune diseases.
- •- Pre-existent lung disease
- •- Upper airway / esophageal pathology
- •- Recent (< 1 month) nasal bleeding
- •- Phrenic nerve lesions
- •- Any metals in body (pacemaker, splinters, metal stitches)
研究者
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