Probiotics for Birch Pollen Allergy
- Conditions
- Rhinitis, Allergic, Seasonal
- Interventions
- Biological: Lactobacillus acidophilus and Bifidobacterium lactisBiological: Placebo
- Registration Number
- NCT00746226
- Lead Sponsor
- Danisco
- Brief Summary
Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed to modulate the immune system. Since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy.
Earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. It was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 47
Physician verified birch pollen allergy
Diagnosed asthma Habitual use of probiotics and/or prebiotics
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description A Lactobacillus acidophilus and Bifidobacterium lactis Numbers 509-513, 700-709 and 900-909 Probiotic combination of L. acidophilus and B. lactis B Placebo Numbers 612-624 and 800-811 Microcrystalline cellulose
- Primary Outcome Measures
Name Time Method Birch pollen allergy symptoms March/April and June Nasal Eosinophilia April/May and June
- Secondary Outcome Measures
Name Time Method Change in microbiota composition April/May and June Cytokine profile from serum April/May and June Faecal recovery of administered probiotics April/May and June
Trial Locations
- Locations (1)
Turku University Central Hospital
🇫🇮Turku, Finland