Long-Term Cardiovascular and Cerebrovascular Outcomes After Retinal Artery Occlusion: A Nationwide Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15,000
- 试验地点
- 1
- 主要终点
- Occurrence of MACCE
研究概览
简要总结
Retinal artery occlusion (RAO) is a rare but vision-threatening vascular disorder that is commonly caused by embolic events originating from the heart or carotid arteries. Patients with RAO are known to have an increased risk of subsequent cardiovascular and cerebrovascular events, including ischemic stroke and myocardial infarction. However, long-term outcomes and optimal medical treatment strategies for these patients remain insufficiently characterized.
The purpose of this nationwide population-based study is to investigate the incidence of long-term cardiovascular and cerebrovascular outcomes in patients diagnosed with retinal artery occlusion using the Korean National Health Insurance Service (NHIS) database. In addition, the study aims to evaluate the impact of various medical therapies, including antiplatelet agents, anticoagulants, and statins, on long-term clinical outcomes.
详细描述
Retinal artery occlusion (RAO) is an acute retinal vascular disease that results in sudden and severe vision loss. RAO is typically classified into central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO), depending on the site of arterial obstruction. CRAO generally has a worse clinical prognosis compared with BRAO.
Previous studies have demonstrated that RAO is associated with systemic vascular diseases and an increased risk of ischemic stroke and other cardiovascular events. Despite its clinical significance, effective evidence-based treatment strategies for RAO remain unclear.
This study aims to evaluate the epidemiology and long-term cardiovascular outcomes of patients with RAO in Korea using the National Health Insurance Service (NHIS) database, which covers nearly the entire Korean population. Patients newly diagnosed with RAO between January 2010 and December 2024 will be identified.
This nationwide population-based study may help clarify the long-term prognosis of RAO and identify optimal medical treatment strategies for improving clinical outcomes in these patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients newly diagnosed with retinal artery occlusion
排除标准
- •Patients with a prior diagnosis of retinal artery occlusion before the study period.
- •Patients diagnosed with giant cell arteritis.
研究组 & 干预措施
Patients who underwent retinal artery occlusion
Among the total cohort, patients who underwent retinal artery occlusion were selected.
干预措施: retinal artery occlusion (Other)
Matched cohort
Among the total cohort, 1:6 age- and sex-matched subjects without retinal artery occlusion using a propensity score were generated.
结局指标
主要结局
Occurrence of MACCE
时间窗: up to 5 years
major adverse cardiovascular and cerebrovascular event
次要结局
- Occurrence of all-cause death(up to 5 years)
- Occurrence of cardiac death(up to 5 years)
- Occurrence of myocardial infarction(up to 5 years)
- Occurrence of stroke(up to 5 years)
- Occurrence of revascularization(up to 5 years)
- Occurrence of admission due to heart failure(up to 5 years)
- Occurrence of atrial fibrillation(up to 5 years)
- Occurrence of major and clinically relevant non-major bleeding(up to 5 years)
研究者
Seung Hun Lee
Associate Professor
Chonnam National University Hospital