VDR SNPs & 25OHD Correlated With Dyslipidemia

Completed

• Conditions: Single Nucleotide Polymorphism; Dyslipidemias

• Registration Number: NCT04707612
• Lead Sponsor: Shenzhen Center for Chronic Disease Control

Brief Summary

The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07-01
• Primary Completion: 2014-01-31
• Study Completion: 2016-10-31
• Status Verified: 2021-01
• Study First Submitted: 2021-01-10
• Study First Submitted QC: 2021-01-12
• Last Update Submitted: 2021-01-12
• Study First Posted: 2021-01-13
• Last Update Posted: 2021-01-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1987

Inclusion Criteria

• 1. ≥ 20 years old Han Chinese;
• 2. living in Shenzhen for > 2 years;
• 3. free of liver diseases, renal diseases, and any cancers in the past 6 months; and
• 4. not in pregnancy for women.

Exclusion Criteria

• 1. had severe organic diseases,
• 2. had acute infection symptoms, allergic diseases, and malignant tumors,
• 3. had a family history of genetic diseases,
• 4. took VD supplements in the past 6 months,
• 5. took medicines to control lipid levels within 12 hours, or
• 6. took diuretics, did strenuous exercise, or overate within 24 hours before the test.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
25OHD	6 months	Plasma 25-hydroxyvitamin D concentration
SNPs of VDR	6 months	Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1
lipid profiles	6 months	Serum concentrations of TG, TC, LDLC, and HDLC

Trial Locations

Locations (1)

Shenzhen Center for Chronic Disease Control; 🇨🇳 Shenzhen, Guangdong, China