Citrate Anticoagulation for Postdilution Hemofiltration
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Filter running time
研究概览
简要总结
This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.
详细描述
Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects.
We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol.
We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute kidney injury
- •critical illness and treatment at ICU
排除标准
- •age < 18 years
- •pregnancy or breast feeding
- •severe lactate acidosis ( > 10 mmol/l) for longer than 6 hours and pH < 7.2
结局指标
主要结局
Filter running time
时间窗: 72 hours
Filterlifetime with regional citrate anticoagulation for haemofiltration
次要结局
未报告次要终点
研究者
Klinik für Anästhesiologie
Prof. Dr. D. Kindgen-Milles
Heinrich-Heine University, Duesseldorf