NCT01394419
Completed
Phase 4
Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft
Overview
- Phase
- Phase 4
- Intervention
- N-acetylcysteine
- Conditions
- Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft
- Sponsor
- Yonsei University
- Enrollment
- 115
- Locations
- 1
- Primary Endpoint
- Incidence of acute kidney injury
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
N-acetylcysteine may prevent acute kidney injury in high risk patients undergoing off-pump coronary artery bypass graft.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing off-pump coronary artery bypass surgery and meets more than one of the following criteria;
- •preoperative serum creatinine \> 1.4 mg/dl
- •Age \> 70 years
- •Diabetes mellitus
- •left ventricular ejection fraction \< 35 % or congestive heart failure (NYHA III or IV)
- •emergency surgery or re-operation
Exclusion Criteria
- •preoperative acute renal failure, patients on dialysis, use of N-acetylcystein within 5 days of surgery, history of hypersensitivity to N-acetylcystein
Arms & Interventions
NAC group
N-acetylcysteine
Intervention: N-acetylcysteine
Placebo group
Saline
Intervention: Saline
Outcomes
Primary Outcomes
Incidence of acute kidney injury
Time Frame: within 5 days after surgery
Study Sites (1)
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