Genomic Risk in Retroperitoneal Sarcoma
- Conditions
- Soft Tissue SarcomaRetroperitoneal Liposarcoma
- Registration Number
- NCT06436846
- Lead Sponsor
- Fox Chase Cancer Center
- Brief Summary
The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled from quadrants within and remote from the primary tumor and is subsequently subjected to genetic analyses looking for such predisposing factors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Adult patients (age ≥18 years).
- Histologically confirmed retroperitoneal liposarcoma via preoperative biopsy, or cross-sectional imaging suspicious for liposarcoma with planned surgical resection
- Will be undergoing surgical resection for treatment of primary or recurrent disease
- Have provided informed consent to participate in this study
• Prior surgical anatomy which makes sampling of remote areas of the retroperitoneum technically impossible or clinically undesirable for safety reasons
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence of MDM2 amplification in "normal" retroperitoneal fat Through study completion, an average of 3 years MDM2 amplification of primary tumors and fat samples will be tested by immunohistochemistry and/or fluorescence in situ hybridization.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center🇺🇸Philadelphia, Pennsylvania, United StatesAnthony Villano, MDContact215-728-3686anthony.villano@fccc.eduMargaret vonMehren, MDSub InvestigatorAndres Correa, MDSub InvestigatorJeffrey Farma, MD, FACSSub InvestigatorStephanie Greco, MD, FACSSub InvestigatorAlexander Kutikov, MD, FACSSub InvestigatorSanjay Reddy, MD, FACSSub InvestigatorLori Rink, PhDSub InvestigatorMarc Smaldone, MD, MSHP, FACSSub InvestigatorRobert Uzzo, MD, MBA, FACSSub InvestigatorRosalia Viterbo, MD, FACSSub InvestigatorShuanzeng Wei, MD, PhDSub InvestigatorJohnathan Whetstine, PhDSub InvestigatorMargaret von Mehren, MDSub Investigator