Healing without faecal incontinence - a comparison of cutting seton versus ligation of intersphincteric fistula tract (LIFT) for complex cryptoglandular fistula-in-ano: a prospective, multi-center, randomized trial

St George Hospital0 个研究点目标入组 200 人开始时间: 2024年5月2日最近更新: 2024年5月6日

适应症

试验速览

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•Adult patients (18 years and over) with complex cryptoglandular anal fistula requiring operative management
•Complex fistulae are defined as high trans- sphincteric or supra-sphincteric fistulas, anteriorly situated fistulas in women, fistula disease in the presence of impaired continence, and any recurrent fistulas
•Able to give valid consent
•Current loose seton in situ for control of perianal sepsis
•Deemed by treating surgeon based on imaging (endoanal ultrasound or MR) or examination under anaesthesia to be suitable for LIFT or cutting seton (based on anatomy of the tract)

•Fistula anatomy or patient deemed unsuitable by the treating surgeon for either cutting seton or LIFT
•Inflammatory bowel disease – currently active or known history
•Secondary/non-cryptoglandular aetiology (ie. radiation, trauma, malignancy)
•Active immunosuppression (diabetes excepted)
•Patients defunctioned with a stoma

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