Impact of toothbrushing in the prevention of pneumonia in Intensive Care Unit - IC
Not Applicable
- Conditions
- Ventilator-Associated PneumoniaC01.539.248.500
- Registration Number
- RBR-4twh4m
- Lead Sponsor
- niversidade Federal de Pernambuco
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Individuals with age equal or greater than 18 years; submitted to endotracheal intubation; expected to remain on mechanical ventilation for >48 hours; without evidence of pulmonary infection at Intensive Care Unit admission.
Exclusion Criteria
Individuals without teeth; suspicion of pneumonia at the time of endotracheal intubation; pregnancy; tracheostomy; chlorhexidine allergy.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of incidence of ventilator-associated pneumonia (VAP), expressed in percentage as episodes per patients under mechanical ventilation, and differences between the groups with p values ??with 95% confidence interval. ;Among the 213 patients, ventilatior-associated pneumonia occurred in 45 (21.1%), 28 (62,2%) being patients from the control group and 17 (37,8%) from the intervention group, with global incidence density equal to 14.2 by 1.000 MV/day. The use of toothbrushing plus 0.12% chlorhexidine gel demonstrated a lower incidence of VAP throughout the follow up period, although the difference was not statistically significant (p = 0.084).
- Secondary Outcome Measures
Name Time Method Identify differences in mortality rate, duration of mechanical ventilation and length of hospital stay in Intensive Care Unit (ICU) between the studied groups, with p values ??with 95% confidence interval.;As to the mortality, among the 213 patients, death occurred in 47 (22,06%); 27 (57,5%) being patients from the control group and 20 (42,5%) from the intervention group.<br>The relative risk of death (RR=1,41) was higher in the control group, increasing the risk of death by 41%, although it was not statistically significant (p=0,296).<br>Regarding the length of hospital stay in the ICU, the difference was not statistically significant (p= 0.064).<br>There was a significant reduction of the mean time of mechanical ventilation in the group of patients who were submitted to toothbrushing (p= 0.018).