Predicitve value of the brain biomarker Neuron Specific Enolase in prognostication of patients with Traumatic and Ischemic Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Predictive valu of Neuron Specific Enolase ICU mortality
研究概览
简要总结
Biomarkers are objective indicators used to assess normal or pathological processes, evaluate responses to treatment and predict outcomes
Serum biomarkers were listed into the following broad categories for ease of discussion immune markers and markers of inflammation, hormones as biomarkers coagulation and vasculature genetic polymorphisms antioxidants and oxidative stress, apoptosis and degradation pathways and protein markers.
Traumatic brain injury (TBI) and Stroke are responsible for the majority of neurology cause of death and are leading cause of disability .
Outcome prognostication in ischemic stroke patients remains challenging due to limited predictive properties of existing models. Blood-based biomarkers might provide additional information to established prognostic factors.
Glial fibrillary acidic protein (GFAP) S100, and neurons specific enolase (NSE) were the most prominent and frequently cited markers
Aim of the study is to know the trends of NSE in Stroke and TBI .
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •1 All patients with TBI of moderate to severe grades as defined by BTF guidelines presenting with in 24hrs of injury 2 All patients with Acute Ischaemic Stroke with ASPECTS score less than 6 presenting with in 24hrs of symptoms.
排除标准
- •1 Age less than 18 years 2 Pregnancy 3 Recent Neurosurgery less than 12 weeks 4 No consent.
结局指标
主要结局
Predictive valu of Neuron Specific Enolase ICU mortality
时间窗: At time of admission and after 24hrs of first sample
in ICU
时间窗: At time of admission and after 24hrs of first sample
次要结局
- GCOS at ICU discharge(Hospital Mortality)
研究者
Dr J M Ganshyam
Medicover Hospitals