Exercise rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy: Impact and mechanisms

Not Applicable

Recruiting

• Conditions: cancer; chemotherapy-induced peripheral neuropathy; Cancer - Any cancer; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation; Public Health - Health service research

• Registration Number: ACTRN12619001093178
• Lead Sponsor: niversity of New South Wales

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-08-08
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1.Grade 2 or 3 chemotherapy-induced peripheral neuropathy (symptoms affecting function)
2.At least 3 months post-neurotoxic cancer treatment and not planned for neurotoxic cancer treatment in the next 8 weeks
3.Previously treated with cancer treatments for which neuropathy is a known side effect
4.Greater than 18 years of age
5.Able to provide written informed consent
6.Cleared by a physician to participate in a structured exercise program

Exclusion Criteria

1.Eastern Cooperative Oncology Group (ECOG) performance status equal to or greater than 3
2.Patients with known peripheral neuropathy prior to neurotoxic cancer treatment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the effect of a clinic exercise intervention with usual care on chemotherapy-induced peripheral neuropathy symptoms using The Total Neuropathy Score, clinical (TNSc).<br><br>[Baseline, Week 8 (post-intervention; primary endpoint), 6 month post-intervention follow-up];To compare the effect of a clinic exercise intervention with usual care on patient function including The 6-minute walk test [Baseline, Week 8 (post-intervention; primary endpoint), 6 month post-intervention follow-up];To compare the effect of a clinic exercise intervention with usual care on patient function including postural sway assessment (using Swaymeter).[Baseline, Week 8 (post-intervention; primary endpoint), 6 month post-intervention follow-up]