Muscle Inflammation and Fat Infiltration in Patients Affected by FSHD
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Muscle inflammation
研究概览
简要总结
Facioscapulohumeral muscular dystrophy (FSHD) is the second most common muscular dystrophy with approximately 500 patients in Denmark. It is characterized by weakness and wasting of the facial muscles, the muscles in the shoulder region and of the legs.
The primary aim of this study is to investigate possible links and order between inflammation and fat infiltration in the muscles in patients with FSHD.
Approximately 15 patients with FSHD will be recruited for repeated MRI-scans during a year where the inflammation and fat infiltration in the muscles can be quantified.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed FSHD
排除标准
- •All contraindications for undergoing an MRI scan
结局指标
主要结局
Muscle inflammation
时间窗: One MRI scan per subject (exam lasts approximately 60 min.)
MRI (t2 mapping) will be used to quantify the inflammation in skeletal muscle.
Muscle fat fraction
时间窗: One MRI scan per subject (exam lasts approximately 60 min.)
The Dixon MRI will be used to quantify the fat fraction in skeletal muscle.
次要结局
- Muscle strength(One muscle strength test per subject (exam lasts approximately 60 min.))
研究者
Julia Dahlqvist, MD
MD
Rigshospitalet, Denmark