Hypertrophic Cardiomyopathy: A Burden of Illness Study In India- Retrospective study

Hypertrophic cardiomyopathy HCM is a genetic heart disease, inherited in an autosomal dominant pattern and accounts for 88 percentage of the world population. HCM is one of the most common phenotypes of cardiomyopathy. HCM is defined as a disease state in which morphologic expression is confined solely to the heart. It is characterized predominantly by left ventricular hypertrophy LVH in the absence of another cardiac or systemic or metabolic disease capable of producing the magnitude of hypertrophy evident in a given patient and for which a disease causing sarcomere or sarcomere related variant is identified or genetic etiology remains unresolved.

In India the disease burden of patients with HCM is not well understood. There are very few publications articles that capture the burden of HCM in India and no comprehensive account or publication exists at a national level. Therefore this study aims to generate evidence on prevalence and mortality from literature clinical burden health care resource utilization HCRU and health related quality of life HRQoL especially for patients with obstructive HCM and non obstructive HCM in India. The data derived from this study could be used for development of economic modeling such as cost effectiveness analysis budget impact models etc.

This study provides the opportunity to collect data out of controlled conditions. The study findings can be utilized for better understanding of the burden of HCM in real world clinical practice. Although the sample size of included population is small this study will set a platform for further research on a wider scale with longer follow ups to provide more robust data on burden of illness of HCM in Indian population.