跳至主要内容
临床试验/CTRI/2020/08/027263
CTRI/2020/08/027263尚未招募不适用

Effects of Postural Recruitment Maneuver and Positive End-Expiratory Pressure on Lung Atelectasis during Laparoscopic Cholecystectomy Surgery: A prospective, randomized study

AIIMS Rishikesh1 个研究点 分布在 1 个国家目标入组 130 人开始时间: 2020年1月9日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
130
试验地点
1
主要终点
Lung atelectasis assessed by ultrasound

研究概览

简要总结

General anaesthesia leads to lung atelectasis, even in healthy parenchyma. This pathophysiologic alteration is a result of decrease in functional residual capacity and respiratory compliance, due to compression of lung parenchyma by abdominal viscera, especially in dependent areas of lung. The creation of pneumoperitoneum during laparoscopic surgery further augments these changes, leading to increased risk of hypoxemia and pulmonary complications during perioperative period. Mechanical ventilation by-itself is insufficient to offset these compressive effects due to low transpulmonary pressure, especially in gravity-dependent zones of lung. Different approaches have been tried to minimize these changes, including head-up position, application of intraoperative positive end expiratory pressure (PEEP), or recruitment maneuver (RM) etc. The RM has been found to most effective in reverting atelectasis, among all strategies. However, potential hemodynamic complications of high transthoracic pressures by RM require close haemodynamic monitoring of such patients, especially in laparoscopic surgery exposing the patient to detrimental effects of capnoperitoneum. Postural recruitment maneuver (PRM) have been suggested as an effective and efficient low risk alternative to RM in a recent brief communication. Changing the body position while applying PEEP of 10 cmH2O for just 3 min, prevented atelectasis in mechanically ventilated children under general anaesthesia. Our aim is to assess the effects of postural recruitment maneuver and positive end-expiratory pressure on lung atelectasis during laparoscopic cholecystectomy surgery.

研究设计

研究类型
Interventional
分配方式
Computer generated randomization
盲法
Participant and Outcome Assessor Blinded

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • American Society of Anaesthesiologists class I and II, posted for elective laparoscopic cholecystectomy surgery.

排除标准

  • Obesity (Body Mass Index >40 kg/square metre) History of cardiovascular or respiratory disease Previous chest surgery Pregnancy Patients with contraindication to PEEP initiation such as raised intracranial pressure and hypotension.

结局指标

主要结局

Lung atelectasis assessed by ultrasound

时间窗: Baseline (5 minutes after general anaesthesia induction), 5 minutes before creating pneumoperitoneum, and just before terminating pneumoperitoneum

次要结局

  • Arterial blood gas parameters including PaO2, PaCO2, pH, HCO3-(Baseline (5 minutes after general anaesthesia induction), 5minutes before creating pneumoperitoneum, and just before terminating pneumoperitoneum)
  • Ventilatory parameters including Ppeak, Pmean, Pplat and tidal volume(Baseline (5 minutes after general anaesthesia induction), 5 minutes before creating pneumoperitoneum, and just before terminating pneumoperitoneum)
  • Duration of surgery(Intraoperative period)
  • Intraoperative complications(Intraoperative period)

研究者

申办方类型
Government medical college

研究点 (1)

Loading locations...

相似试验