The effect of Supplemetation of ?3 and its combination with Vitamin E in Coronary Artery Disease(CAD).
- Conditions
- coronary artery Disease.Atherosclerotic heart disease
- Registration Number
- IRCT2013080514273N1
- Lead Sponsor
- tehran university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 60
? BMI less than 30
? aged 65-45 years
? More than 50% of patients with at least one coronary artery stenosis confirmed by angiography in three months
? Lack of PPAR? agonist drugs such Tyazvlydyn Dion (TZDs), and fiber and taking angiotensin receptor type 1 blockers and inhibitors of non-ACE,
? willingness to cooperate
Criteria excluded:
? kidney disease, liver disease, diabetes, cancer, thyroid disorders, according to the patient's medical history
? smoking (at least 5 threads in the last 6 months)
? omega-3 supplements or fish oil and vitamin E for three months
? Allergy and sensitivity to fish oil
? Lack of cooperation is likely to continue.
Mbar excluded
Any drastic changes in diet (the doctor, the patient himself)
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gene expression of adiponectin in PBMC. Timepoint: Baseline, After8 weeks. Method of measurement: Realtime PCR.;Gene expression of adiponectin receptors , R1 and R2 in PBMC. Timepoint: Baseline , after 8 weeks. Method of measurement: Realtime PCR.;Gene expression of PPAR gamma in PBMC. Timepoint: Baseline , after 8 weeks. Method of measurement: Realtime PCR.;Serum A-FABP. Timepoint: Baseline , after 8 weeks. Method of measurement: ELISA.;Serum hs-CRP. Timepoint: Baseline , after 8 weeks. Method of measurement: ELISA.;Serum adiponectin. Timepoint: Baseline , after 8 weeks. Method of measurement: ELISA.;Adiponectin / A-FABP. Timepoint: Baseline , after 8 weeks. Method of measurement: Calculate.;Systolic Blood pressure. Timepoint: Baseline , after 8 weeks. Method of measurement: Mercury Sphygmomanometer.;Diastolic Blood pressure. Timepoint: Baseline , after 8 weeks. Method of measurement: Mercury Sphygmomanometer.
- Secondary Outcome Measures
Name Time Method