Providing a comprehensive neuropsychological rehabilitation program that is focused on restoring language and cognitive deficits for patients suffering from post stroke aphasia.
- Conditions
- Health Condition 1: null- Patients suffering from 1st time ischemic stroke suffering from post-stroke aphasia.
- Registration Number
- CTRI/2014/04/004554
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
1.Any Education level
2.Language: Both Hindi and/or English
3.Handedness: Right
4.Patients suffering first-time ischemic stroke diagnosed with non-fluent or fluent aphasia within a year of index event.
5.All consenting patients
6.Care giver (taking up the role of home based therapist) is available who has frequent contact with the subject (e.g. an average of 10 hours per week or more), and can accompany the subject to all clinic visits for the duration of the rehabilitation program.
1.Patients suffering from more than one episode of stroke affecting language and cognition.
2.Any medical condition limiting life expectancy
3.Any major neurological disorder affecting cognition
4.Any major psychiatric disorder
5.Use of psychoactive drugs
6.Active participation in other stroke recovery trials testing experimental intervention about cognition.
7.Pregnant women.
8.Patients with any contraindication for MRI.
9.Patients having claustrophobia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The impact of the Comprehensive Neuropsychological Rehabilitation on patients suffering from post-stroke aphasia would be measured through: <br/ ><br>1.Change in the scores of Language functioning from pre to post intervention in the following domains- <br/ ><br>â?¢Acoustic Problems <br/ ><br>â?¢Speech and Language Problems <br/ ><br>â?¢Simple Mathematical Problems <br/ ><br>â?¢Perceptuo-Motor and Writing Problems <br/ ><br>â?¢Visual and Reading Problems <br/ ><br>2.Change in the scores from pre to post intervention of Quality of life <br/ ><br>Timepoint: The short term effectiveness of the intervention post 1 month of comprehensive neuropsychological rehabilitation with aphasia therapy.
- Secondary Outcome Measures
Name Time Method Change in scores from pre to post intervention of the following: <br/ ><br>1.Cognitive Functioning: <br/ ><br>â?¢Memory <br/ ><br>â?¢Attention <br/ ><br>â?¢Executive functioning <br/ ><br>2.Depression <br/ ><br>3.Correlate with changes in Neural Activations (Imaging using fMRI) <br/ ><br>Timepoint: The long term effectiveness of the intervention post 3 months of comprehensive neuropsychological rehabilitation with aphasia therapy with the use of fMRI.