Treatment Optimization and Nephrolithiasis Recurrence Prevention With Interdisciplinary Care

Recruiting

• Conditions: Kidney Stone

• Registration Number: NCT06367894
• Lead Sponsor: Agnieszka Pozdzik

Brief Summary

Nearly 10% of the Belgian population suffer from kidney stone disease. Recent reviews reported that kidney stones represent an underestimated risk factor for further kidney function deterioration. Preventive measures are recommended in lithiases patients to prevent the formation of new stones. The individual effects of different medicated prosthetic interventions have been documented in clinical trials. However, there is little data on the effectiveness of combining these different preventive measures in routine clinical practice (real-world context).

Patients with kidney stone disease require a complete metabolic assessment. The three main factors contributing to the stone's formation are the patient's metabolism, diet and lifestyle. Metabolic work-up is recommended by the American Urology Association to identify and correct the factors responsible for urinary stone formation such as hypercalciuria, hyperoxaluria, hyperuricuria, hypocitraturia or abnormalities of urinary pH. The metabolic work-up includes at minimum the 24h urine test, a blood test and spot urine test. Dietary habits and lifestyle are assessed by means of a questionnaire.

The CHU Brugmann Hospital has a specialized multidisciplinary clinic for renal lithiases and mineral metabolism. Preventive personalized and interdisciplinary care in CHU Brugmann consists of a full metabolic work-up allowing the identification of lithogenic risk factors by nephrologists, dietary assessment by specialized dieticians and specific treatment protocol associated with regular follow-up.

The aim of this study is to evaluate, in the context of a retrospective single-center cohort study, the effect of preventive personalized and interdisciplinary care on the evolution of all urinary lithogenic risk factors and the recurrence of kidney stones (rate of renal colics, emergency room admissions, and urological interventions).

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-12
• Status Verified: 2024-04
• Study First Submitted: 2024-04-11
• Study First Submitted QC: 2024-04-11
• Last Update Submitted: 2024-04-11
• Study First Posted: 2024-04-16
• Last Update Posted: 2024-04-16
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 164

Inclusion Criteria

• All patients of the CHU Brugmann Hospital who fulfill the criteria of active or past history of kidney stone, from 01/01/2018 till 31/10/2023
• Minimum follow-up time of 2 months with biochemical and clinical results available

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of emergency admissions	From first patient consultation till 31/10/2023	Number of emergency admissions
Wisconsin questionnaire	From first patient consultation till 31/10/2023	Changes in the quality of life in the patients (evolution of the scoring of the Wisconsin questionnaire)
Identified genetics abnormalities	From first patient consultation till 31/10/2023	List of identified genetics abnormalities
Number of hospitalizations	From first patient consultation till 31/10/2023	Number of hospitalizations
Number of surgeries	From first patient consultation till 31/10/2023	Number of surgeries
Number of acute renal colics	From first patient consultation till 31/10/2023	Number of acute renal colics
Kidney function outcome	Status at 31/10/2023	Kidney function outcome

Trial Locations

Locations (1)

CHU Brugmann; 🇧🇪 Brussels, Belgium