A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
- Conditions
- Colitis, Ulcerative
- Interventions
- Registration Number
- NCT05242484
- Lead Sponsor
- Janssen Research & Development, LLC
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss of response, or intolerance to one or more approved advanced therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 577
- Confirmed diagnosis of ulcerative colitis (UC) for at least 3 months prior to baseline
- Moderately to severely active UC as assessed by the modified Mayo score
- Demonstrated inadequate response, loss of response, or intolerance to at least one biologic or novel oral with biologic-like activity
- If female and of childbearing potential, must meet the contraception and reproduction requirements
- Has severe extensive colitis as defined in the protocol
- Extent of inflammatory disease limited to the rectum
- Participants with current diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, or Crohn's disease (CD)
- Has a history of, or ongoing, chronic or recurrent infectious disease, including but not limited to, sinopulmonary infections, bronchiectasis, recurrent renal/urinary tract infections (example, pyelonephritis, cystitis), an open, draining, or infected skin wound, or an ulcer
- Currently has a malignancy or a history of malignancy within 5 years before screening (with the exception of nonmelanoma skin cancer or cervical carcinoma in situ that has been treated with no evidence of recurrence within 12 months of first dose of study intervention)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group 4: JNJ-78934804 (High-dose) JNJ-78934804 Participants will receive JNJ-78934804 dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 1: Placebo Placebo Participants will receive placebo subcutaneously (SC). All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 5: JNJ-78934804 (Mid-dose) JNJ-78934804 Participants will receive JNJ-78934804 dose regimen 2 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 6: JNJ-78934804 (Low-dose) JNJ-78934804 Participants will receive JNJ-78934804 dose regimen 3 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 2: Guselkumab Guselkumab Participants will receive guselkumab dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 3: Golimumab Golimumab Participants will receive golimumab dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
- Primary Outcome Measures
Name Time Method Percentage of Participants with Clinical Remission at Week 48 Week 48 Percentage of participants with clinical remission at Week 48 will be reported. Clinical remission based on the modified Mayo subscores.
- Secondary Outcome Measures
Name Time Method Serum Concentrations of Guselkumab Over Time Up to Week 48 Serum concentrations of guselkumab over time will be reported. Serum samples will be analyzed to determine concentrations of guselkumab using a validated, specific, and sensitive method.
Percentage of Participants with Endoscopic Improvement at Week 48 Week 48 Percentage of participants with endoscopic improvement at Week 48 will be reported. Endoscopic improvement at Week 48 based on the Mayo endoscopic subscore.
Percentage of Participants with Corticosteroid-free Clinical Remission at Week 48 Week 48 Percentage of participants with corticosteroid-free (60-day) clinical remission at Week 48 will be reported.
Percentage of Participants with Symptomatic Remission at Week 48 Week 48 Percentage of participants with symptomatic remission at Week 48 will be reported. Symptomatic remission at Week 48 based on stool and rectal bleeding symptoms.
Percentage of Participants with Combination of Histological Remission and Endoscopic Improvement at Week 48 Week 48 Percentage of participants with combination of histological remission and endoscopic improvement at Week 48 will be reported. Histologic remission and endoscopic improvement at Week 48 based on the histologic grading and the Mayo endoscopy subscore.
Secondary Comparison: Percentage of Participants with Clinical Remission at Week 48 Week 48 Percentage of participants with clinical remission at Week 48 will be reported. Clinical remission based on the modified Mayo subscores will be reported.
Percentage of Participants with Adverse Events (AEs) Up to Week 48 An AE is any untoward medical occurrence in a clinical study participant administered a pharmaceutical (investigational or non-investigational) product. An AE does not necessarily have a causal relationship with the intervention.
Percentage of Participants with Serious Adverse Events (SAEs) Up to Week 48 A SAE is any untoward medical occurrence that at any dose: results in death; is life-threatening; requires inpatient hospitalization or prolongation of existing hospitalization; results in persistent or significant disability/incapacity; is a congenital anomaly/birth defect; is a suspected transmission of any infectious agent via a medicinal product; is medically important.
Laboratory Parameters Over Time Up to Week 48 Laboratory parameters over time will be reported.
Vital Signs Parameters Over Time Up to Week 48 Vital signs parameters over time will be reported.
Suicidal Ideation Assessment Using Columbia Suicide Severity Rating Scale (C-SSRS) Score Up to Week 48 The C-SSRS scale consists of 28 items in 4 sections: suicide behavior, actual attempts, suicidal ideation, and intensity of ideation. Worsening of suicidal ideation was an increase in severity of suicidal ideation from baseline.
Serum Concentrations of Golimumab Over Time Up to Week 48 Serum concentration of golimumab over time will be reported. Serum samples will be analyzed to determine concentrations of golimumab using a validated, specific, and sensitive method.
Percentage of Participants with Antibodies to Guselkumab Up to Week 48 Percentage of participants with antibodies to guselkumab will be reported.
Titers of Antibodies to Guselkumab Up to Week 48 Titers of antibodies to guselkumab will be reported.
Percentage of Participants with Antibodies to Golimumab Up to Week 48 Percentage of Participants with Antibodies to golimumab will be reported.
Titers of Antibodies to Golimumab Up to Week 48 Titers of antibodies to golimumab will be reported.
Percentage of Participants with Neutralizing Antibodies to Guselkumab Up to Week 48 Percentage of participants with neutralizing antibodies to guselkumab will be reported.
Percentage of Participants with Neutralizing Antibodies to Golimumab Up to Week 48 Percentage of participants with neutralizing antibodies to golimumab will be reported.
Trial Locations
- Locations (389)
Praxisgemeinschaft Jerichow
🇩🇪Jerichow, Germany
Eugastro GmbH
🇩🇪Leipzig, Germany
Staedtisches Klinikum Lueneburg
🇩🇪Lueneburg, Germany
Universitaetsklinikum Mannheim
🇩🇪Mannheim, Germany
Gastroenterologische Gemeinschaftspraxis Minden
🇩🇪Minden, Germany
Klinikum der Universitaet Muenchen
🇩🇪Munich, Germany
Praxis fur Innere Medizin und Gastroenterologie
🇩🇪Munster, Germany
MVZ Portal 10
🇩🇪Münster, Germany
Medius Klinik Nürtingen
🇩🇪Nürtingen, Germany
Siloah St Trudpert Klinikum
🇩🇪Pforzheim, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH
🇩🇪Saarbrücken, Germany
Universitaetsklinik Tuebingen
🇩🇪Tübingen, Germany
Universitatsklinikum Ulm
🇩🇪Ulm, Germany
Gemeinschaftspraxis Jakobeit
🇩🇪Wipperfürth, Germany
Universitatsklinikum Wurzburg
🇩🇪Würzburg, Germany
Sotiria General State Hospital of Chest Diseases
🇬🇷Athens, Greece
Alexandra General Hospital of Athens
🇬🇷Athens, Greece
Nikaia General Hospital
🇬🇷Piraievs, Greece
Hippokration Hospital
🇬🇷Thessaloniki, Greece
Obudai Egeszsegugyi Centrum Kft
🇭🇺Budapest, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont
🇭🇺Budapest, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Pannónia Magánorvosi Centrum Kft
🇭🇺Budapest, Hungary
Bugat Pal Korhaz
🇭🇺Gyongyos, Hungary
Szegedi Tud Egyetem Szent Gyorgyi Albert Klin Kozp
🇭🇺Szeged, Hungary
Markusovszky Egyetemi Oktatokorhaz
🇭🇺Szombathely, Hungary
M S Ramaiah Medical College and Hospital
🇮🇳Bangalore, India
Oslo University Hospital HF Ulleval sykehus
🇳🇴Oslo, Norway
Universitetssykehuset Nord-Norge HF
🇳🇴Tromso, Norway
Szpital Uniwersytecki No2
🇵🇱Bydgoszcz, Poland
Centrum Medyczne Plejady
🇵🇱Krakow, Poland
Centrum Medyczne Promed
🇵🇱Krakow, Poland
AmiCare Centrum Medyczne
🇵🇱Lodz, Poland
ETG Lublin
🇵🇱Lublin, Poland
Gastromed Spotka Z Ograniczona Odpowiedzialnoscia Sp. K.
🇵🇱Lublin, Poland
Allmedica
🇵🇱Nowy Targ, Poland
Wojewodzki Szpital Specjalistyczny w Olsztynie
🇵🇱Olsztyn, Poland
Synexus Polska Sp z o o
🇵🇱Poznan, Poland
Twoja Przychodnia
🇵🇱Poznan, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
Endoskopia Sp z o.o.
🇵🇱Sopot, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
Sonomed Sp. z o.o.
🇵🇱Szczecin, Poland
GASTROMED Sp. z o.o.
🇵🇱Torun, Poland
Centrum Zdrowia Matki Dziecka i Mlodziezy
🇵🇱Warszawa, Poland
Centralny Szpital Kliniczny Mswia
🇵🇱Warszawa, Poland
Reumatika-Centrum Reumatologii, NZOZ
🇵🇱Warszawa, Poland
NZOZ Vivamed
🇵🇱Warszawa, Poland
Bodyclinic Sp. z o.o. sp. k
🇵🇱Warszawa, Poland
Groote Schur Hospital
🇿🇦Cape Town, South Africa
Practice Dr Naeem Moosa
🇿🇦Johannesburg, South Africa
Emmed Research
🇿🇦Pretoria, South Africa
Hosp Clinic de Barcelona
🇪🇸Barcelona, Spain
Hosp. Univ. La Paz
🇪🇸Madrid, Spain
Hosp. de Navarra
🇪🇸Pamplona, Spain
Hosp. Montecelo
🇪🇸Pontevedra, Spain
Corporacio Sanitari Parc Tauli
🇪🇸Sabadell, Spain
Hosp. Univ. Marques de Valdecilla
🇪🇸Santander, Spain
Hosp. Univ. de Torrejon
🇪🇸Torrejón de Ardoz, Spain
Hosp. Alvaro Cunqueiro
🇪🇸Vigo, Spain
Karolinska Universitetssjukhuset Solna
🇸🇪Solna, Sweden
Matsushima Clinic
🇯🇵Kanagawa, Japan
Irmandade da Santa Casa da Misericórdia de Santos
🇧🇷Santos, Brazil
Hospital Nove de Julho
🇧🇷Sao Paulo, Brazil
BR Trials
🇧🇷Sao Paulo, Brazil
Instituto D Or de Pesquisa e Ensino IDOR
🇧🇷São Paulo, Brazil
Medical Centre Hipocrat
🇧🇬Haskovo, Bulgaria
Diagnostic Consulting Center I Sliven
🇧🇬Sliven, Bulgaria
University Hospital Alexandrovska - Clinic of Nephrology
🇧🇬Sofia-Grad, Bulgaria
UMHAT 'Tsaritsa Yoanna'
🇧🇬Sofia, Bulgaria
Medical Center -Medika Plus
🇧🇬Veliko Tarnovo, Bulgaria
Multriprofile Hospital for Active Treatment Hristo Botev
🇧🇬Vratsa, Bulgaria
Odense Universitetshospital
🇩🇰Odense, Denmark
UZ Gent
🇧🇪Gent, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
CHU de Liege
🇧🇪Liege, Belgium
CHU Amiens - Hopital Sud
🇫🇷AMIENS cedex 1, France
Dartmouth Hitchcock
🇺🇸Lebanon, New Hampshire, United States
CIPREC
🇦🇷Ciudad Autonoma de Buenos Aires, Argentina
CHC MontLegia
🇧🇪Liège, Belgium
Om Research LLC
🇺🇸Lancaster, California, United States
SER - Servicos Especializados em Reumatologia da Bahia
🇧🇷Salvador, Brazil
Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Vitaz
🇧🇪Sint-Niklaas, Belgium
Universidade Estadual Paulista 'Julio De Mesquita Filho'
🇧🇷Botucatu, Brazil
Pesquisare Saude
🇧🇷Santo Andre, Brazil
Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE
🇧🇷Sao Paulo, Brazil
L2IP Instituto de Pesquisas Clinicas
🇧🇷Brasilia, Brazil
Kaplan Medical Center
🇮🇱Rehovot, Israel
Herlev Hospital, University of Copenhagen
🇩🇰Herlev, Denmark
Medical College Of Virginia Hospital
🇺🇸Richmond, Virginia, United States
Rabin Medical Center Beilinson Campus
🇮🇱Petah Tikva, Israel
AZ Maria Middelares
🇧🇪Gent, Belgium
Medical Research Center of Connecticut
🇺🇸Hamden, Connecticut, United States
Alesund sjukehus
🇳🇴Alesund, Norway
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
Care Access Las Vegas
🇺🇸Las Vegas, Nevada, United States
Valley Gastroenterology Medical Group
🇺🇸Arcadia, California, United States
Southern California Research Center
🇺🇸Coronado, California, United States
Vestre Viken HF Baerum Sykehus
🇳🇴Gjettum, Norway
Cedars Sinai Medical Center
🇺🇸Los Angeles, California, United States
University of California San Francisco
🇺🇸San Francisco, California, United States
University of Colorado
🇺🇸Aurora, Colorado, United States
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Yale University
🇺🇸New Haven, Connecticut, United States
MedStar Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
Pioneer Research Solutions Inc.
🇺🇸Coconut Creek, Florida, United States
Digestive and Liver Disease Institute
🇺🇸Kissimmee, Florida, United States
Osceola Regional Hospital
🇺🇸Kissimmee, Florida, United States
Florida Research Center Inc.
🇺🇸Lakewood Ranch, Florida, United States
University of Miami
🇺🇸Miami, Florida, United States
Gastroenterology Group Of Naples
🇺🇸Naples, Florida, United States
Omega Research Consultants
🇺🇸Orlando, Florida, United States
Synergy Clinical Research
🇺🇸Saint Petersburg, Florida, United States
GCP Clinical Research
🇺🇸Tampa, Florida, United States
Atlanta Gastroenterology Associates
🇺🇸Marietta, Georgia, United States
Gastroenterolgy Associates of Central GA
🇺🇸Macon, Georgia, United States
Gastrointestinal Specialists of Georgia
🇺🇸Marietta, Georgia, United States
Gastroenterology Consultants
🇺🇸Roswell, Georgia, United States
Grand Teton Gastroenterology
🇺🇸Idaho Falls, Idaho, United States
IU Health University Hospital
🇺🇸Indianapolis, Indiana, United States
Gastroenterology of Southern Indiana
🇺🇸New Albany, Indiana, United States
Tri-State Gastroenterology Assoc
🇺🇸Crestview Hills, Kentucky, United States
University of Kentucky Chandler Medical Center
🇺🇸Lexington, Kentucky, United States
Jewish Hospital
🇺🇸Louisville, Kentucky, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Brigham And Women's Hospital
🇺🇸Chestnut Hill, Massachusetts, United States
Huron Gastroenterology Associates Center for Digestive Care
🇺🇸Ypsilanti, Michigan, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
Weill Cornell Medical College
🇺🇸New York, New York, United States
Lenox Hill Hospital
🇺🇸New York, New York, United States
Mohawk Valley Endoscopy Center
🇺🇸Utica, New York, United States
University North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Tryon Medical Group
🇺🇸Charlotte, North Carolina, United States
Onsite Clinical Solutions
🇺🇸Charlotte, North Carolina, United States
Care Access Research, Kinston
🇺🇸Kinston, North Carolina, United States
Great Lakes Gastroenterology Research, LLC
🇺🇸Mentor, Ohio, United States
Frontier Clinical Research
🇺🇸Uniontown, Pennsylvania, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Digestive Disease Associates
🇺🇸Rock Hill, South Carolina, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
Etsu Quillen College Of Medicine
🇺🇸Johnson City, Tennessee, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
GI Specialists of Houston
🇺🇸Houston, Texas, United States
Gastroenterology Clinic Of San Antonio P A
🇺🇸San Antonio, Texas, United States
Texas Digestive Disease Consultants
🇺🇸Southlake, Texas, United States
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Washington Gastroenterology, PLLC
🇺🇸Bellevue, Washington, United States
Swedish Medical Center
🇺🇸Seattle, Washington, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
Digestive Health Specialists
🇺🇸Tacoma, Washington, United States
Medical College Of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Hospital de Gastroenterología Dr. Carlos Bonorino Udaondo
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Hospital Britanico de Buenos Aires
🇦🇷Ciudad Autonoma de Buenos Aires, Argentina
Sanatorio Duarte Quiroz
🇦🇷Cordoba, Argentina
Centro de Investigaciones Medicas Mar Del Plata
🇦🇷Mar Del Plata, Argentina
Hospital Provincial del Centenario
🇦🇷Rosario, Argentina
Box Hill Hospital
🇦🇺Box Hill, Australia
Royal Prince Alfred Hospital
🇦🇺Camperdown, Australia
Monash Health, Monash Medical Centre
🇦🇺Clayton, Australia
Concord Hospital
🇦🇺Concord, Australia
Western Health
🇦🇺Footscray, Australia
Coastal Digestive Health
🇦🇺Maroochydore, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Australia
Royal Adelaide Hospital
🇦🇺North Terrace, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Australia
The Alfred Hospital
🇦🇺Prahran, Australia
Mater Hospital Brisbane
🇦🇺South Brisbane, Australia
Universitaetsklinikum Salzburg Landeskrankenhaus
🇦🇹Salzburg, Austria
Klinikum Wels Grieskirchen
🇦🇹Wels, Austria
Krankenhaus der Barmherzigen Brüder
🇦🇹Wien, Austria
Medizinische Universitaet Wien
🇦🇹Wien, Austria
Imelda Ziekenhuis
🇧🇪Bonheiden, Belgium
Algemeen Ziekenhuis Sint-Jan
🇧🇪Brugge, Belgium
Cliniques Universitaires Saint Luc
🇧🇪Bruxelles, Belgium
Chronos Clinica Medica LTDA Chronos Pesquisa Clinica
🇧🇷Brasilia, Brazil
Fundacao Universidade de Caxias do Sul
🇧🇷Caxias Do Sul, Brazil
Centro Digestivo de Curitiba - Instituto de Pesquisa Clínica
🇧🇷Curitiba, Brazil
Associacao Hospitalar Moinhos de Vento
🇧🇷Porto Alegre, Brazil
Hospital De Clinicas De Porto Alegre
🇧🇷Porto Alegre, Brazil
Hospital das Clinicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
Universidade Federal do Rio de Janeiro - Faculdade de Medicina
🇧🇷Rio de Janeiro, Brazil
Foothills Hospital
🇨🇦Calgary, Alberta, Canada
Gastroenterology and Internal Medicine Research Institute (GIRI)
🇨🇦Edmonton, Alberta, Canada
Covenant Health/Grey Nuns hospital
🇨🇦Edmonton, Alberta, Canada
Columbia Gastroenterology
🇨🇦New Westminster, British Columbia, Canada
The Gordon & Leslie Diamond Health Care Center
🇨🇦Vancouver, British Columbia, Canada
GIRI Gastrointestinal Research Institute
🇨🇦Vancouver, British Columbia, Canada
PerCuro Clinical Research Ltd.
🇨🇦Victoria, British Columbia, Canada
Health Sciences Centre
🇨🇦Winnipeg, Manitoba, Canada
Viable Clinical Research
🇨🇦Bridgewater, Canada
Nova Scotia Health Authority
🇨🇦Halifax, Nova Scotia, Canada
London Health Sciences Centre - University Campus
🇨🇦London, Ontario, Canada
Toronto Immune and Digestive Health Institute Inc
🇨🇦Toronto, Ontario, Canada
CMIIM, Centre médical L'Enjeu
🇨🇦Mont-Royal, Quebec, Canada
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
🇨🇦Montreal, Quebec, Canada
McGill University - Health Centre - Montreal General Hospital
🇨🇦Montreal, Quebec, Canada
St. Jerome Medical Research
🇨🇦Saint-Jerome, Quebec, Canada
Hopital Chicoutimi
🇨🇦Saguenay, Canada
China Japan Friendship Hospital
🇨🇳Chaoyang, China
West China Hospital Sichuan University
🇨🇳Chengdu, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Jinhua municipal central hospital
🇨🇳Jinhua, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, China
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
🇨🇳Wuhan, China
Vojenska nemocnice Brno
🇨🇿Brno, Czechia
ISCARE a.s.
🇨🇿Praha 9, Czechia
Aalborg Hospital
🇩🇰Aalborg, Denmark
Aarhus University Hospital
🇩🇰Aarhus, Denmark
Bispebjerg Og Frederiksberg Hospital
🇩🇰Copenhagen, Denmark
Hopital Louis Mourier
🇫🇷Colombes Cedex, France
Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor
🇫🇷Créteil, France
CHU Grenoble
🇫🇷Grenoble, France
Centre Hospitalier Départemental VENDEE
🇫🇷La Roche sur Yon, France
CHRU de Lille Hopital Claude Huriez
🇫🇷Lille, France
Hopital Nord Marseille
🇫🇷Marseille, France
Hopital Saint Eloi
🇫🇷Montpellier, France
Clinique Ambroise Pare
🇫🇷Neuilly-sur-Seine, France
CHU de Nice Hopital de l Archet
🇫🇷Nice cedex 03, France
CHU Nimes Hopital Caremeau
🇫🇷Nîmes, France
Hopital Haut-Leveque, CMC Magellan
🇫🇷Pessac, France
Hospices Civils de Lyon HCL
🇫🇷Pierre Bénite, France
CHU Saint Etienne
🇫🇷Saint Etienne, France
Hopital de Rangueil
🇫🇷Toulouse cedex 09, France
CHRU Nancy Brabois
🇫🇷Vandoeuvre les Nancy, France
Gastroenterologische Spezialpraxis - Berlin-Karlshorst
🇩🇪Berlin-Karlshorst, Germany
Charite Universitaetsmedizin Berlin - Campus Charite Mitte
🇩🇪Berlin, Germany
Praxis Für Gastroenteroligie
🇩🇪Berlin, Germany
Charite - Universitaetsmedizin Berlin (CCM)
🇩🇪Berlin, Germany
Krankenhaus Waldfriede Mitte
🇩🇪Berlin, Germany
University Hospital Dresden
🇩🇪Dresden, Germany
Universitaetsklinik Erlangen
🇩🇪Erlangen, Germany
Agaplesion Frankfurter Diakonie Kliniken GmbH, Markus Krankenhaus
🇩🇪Frankfurt/Main, Germany
JWG-University Hospital
🇩🇪Frankfurt, Germany
Universitatsklinikum Freiburg
🇩🇪Freiburg, Germany
Klinikum Fulda - Tumorklinik - Germany
🇩🇪Fulda, Germany
Martin-Luther-Universitaet Halle-Wittenberg - Universitaetsk
🇩🇪Halle (Saale), Germany
BSF Studiengesellschaft
🇩🇪Halle, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Gastroenterology Outpatient Clinic Prof. Ehehalt/Dr. Hemstäd
🇩🇪Heidelberg, Germany
University Hospital Heidelberg
🇩🇪Heidelberg, Germany
Universitatsklinikum Jena
🇩🇪Jena, Germany
Siksha O Anusandhan University - Institute of Medical Scienc
🇮🇳Bhubaneswar, India
Apex Hospitals Ltd
🇮🇳Jaipur, India
G.B. Pant Hospital
🇮🇳New Delhi, India
All India Institute of Medical Sciences
🇮🇳New Delhi, India
Sir Ganga Ram Hospital
🇮🇳New Delhi, India
Fortis Hospital
🇮🇳New Delhi, India
Yashoda Super Speciality Hospitals
🇮🇳Secunderabad, India
Surat Institute of Digestive Sciences Hospitals
🇮🇳Surat, India
Haemek Medical Center - Afula
🇮🇱Afula, Israel
Rambam Medical Center
🇮🇱Haifa, Israel
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hadassah Hebrew University Medical Center
🇮🇱Jerusalem, Israel
Ofuna Chuo Hospital
🇯🇵Kamakura, Japan
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv Yafo, Israel
The Chaim Sheba Medical Center
🇮🇱Tel Hashomer, Israel
Assaf Harofeh Medical Center
🇮🇱Tzrifin, Israel
Università degli Studi di Bari
🇮🇹Bari, Italy
A.O. Per L' Emergenza Cannizzaro - U.O. Chirurgia Generale
🇮🇹Catania, Italy
AOU Policlinico G.Martino
🇮🇹Messina, Italy
Ospedale San Raffaele HSR Istituto Scientifico Universitario San Raffaele
🇮🇹Milano, Italy
Azienda Ospedaliero Universitaria di Cagliari - Policlinico Duilio Casula di Monserrato
🇮🇹Monserrato, Italy
Azienda Ospedaliera San Gerardo
🇮🇹Monza, Italy
Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar Di Valpolicella, Italy
Ospedale Villa Sofia-Cervello
🇮🇹Palermo, Italy
Università Campus Biomedico di Roma
🇮🇹Roma, Italy
Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Italy
IRCCS Humanitas Rozzano-IBD Center Malattie Infiammatorie Croniche Intestinali
🇮🇹Rozzano, Italy
Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo, Italy
Asahikawa Medical University Hospital
🇯🇵Asahikawa, Japan
Tokyo Medical and Dental University Hospital
🇯🇵Bunkyo Ku, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Japan
Kitakyushu Municipal Medical Center
🇯🇵Fukuoka-ken, Japan
Gifu Prefectural General Medical Center
🇯🇵Gifu, Japan
Tokai University Hachioji Hospital
🇯🇵Hachioji, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu, Japan
National Hospital Organization Hirosaki General Medical Center
🇯🇵Hirosaki, Japan
Hirosaki University Hospital
🇯🇵Hirosaki, Japan
Tokai University Hospital
🇯🇵Isehara, Japan
Kagoshima University Hospital
🇯🇵Kagoshima, Japan
Kagoshima IBD Gastroenterology Clinic
🇯🇵Kagoshima, Japan
Nara Medical University Hospital
🇯🇵Kashihara, Japan
Tsujinaka Hospital Kashiwanoha
🇯🇵Kashiwa, Japan
Kobe University Hospital
🇯🇵Kobe, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu-Shi, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Japan
Kurume University Hospital
🇯🇵Kurume, Japan
University Hospital Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Kyoto University Hospital
🇯🇵Kyoto, Japan
Gunma University Hospital
🇯🇵Maebashi, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Japan
Kyorin University Hospital
🇯🇵Mitaka, Japan
Iwate Medical University Hospital
🇯🇵Morioka, Japan
Nagoya University Hospital
🇯🇵Nagoya, Japan
Nagoya City University Hospital
🇯🇵Nagoya, Japan
The Hospital of Hyogo College of Medicine
🇯🇵Nishinomiya, Japan
Ogaki Municipal Hospital
🇯🇵Ogaki, Japan
Oita Red Cross Hospital
🇯🇵Oita, Japan
Sykehuset Immlandet HF Gjøvik
🇳🇴Gjøvik, Norway
National Hospital Organization Osaka National Hospital
🇯🇵Osaka-shi, Japan
Kinshukai Infusion Clinic
🇯🇵Osaka, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
Japan Community Health Care Organization Osaka Hospital
🇯🇵Osaka, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Japan
Sapporo IBD Clinic
🇯🇵Sapporo Chuo-ku, Japan
Sapporo Tokushukai Hospital
🇯🇵Sapporo, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
🇯🇵Sapporo, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Japan
Tokyo Metropolitan Bokutoh Hospital
🇯🇵Sumida ku, Japan
The Jikei University Hospital
🇯🇵Tokyo, Japan
Tokyo Saiseikai Central Hospital
🇯🇵Tokyo, Japan
National Hospital Organization Tokyo Medical Center
🇯🇵Tokyo, Japan
Tokyo Medical University Hospital
🇯🇵Tokyo, Japan
Oji General Hospital
🇯🇵Tomakomai, Japan
Toyama Prefectural Central Hospital
🇯🇵Toyama, Japan
Toyota Kosei Hospital
🇯🇵Toyota, Japan
University of Tsukuba Hospital
🇯🇵Tsukuba City, Japan
Mie University Hospital
🇯🇵Tsu, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Japan
Istishari Hospital
🇯🇴Amman, Jordan
Jordan University Hospital
🇯🇴Amman, Jordan
Irbid Specialty Hospital
🇯🇴Irbid, Jordan
King Abdullah University Hospital
🇯🇴Irbid, Jordan
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Kosin University Gospel Hospital
🇰🇷Busan, Korea, Republic of
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Chosun university hospital
🇰🇷Gwangju, Korea, Republic of
The Catholic university of Korea, St. Vincent's Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Akershus Universitetssykehus
🇳🇴Lørenskog, Norway
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju, Korea, Republic of
Hallym University Dongtan Sacred Heart Hospital
🇰🇷Hwaseong-si, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St.Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
Academisch Medisch Centrum Universiteit van Amsterdam
🇳🇱Amsterdam, Netherlands
Albert Schweitzer Ziekenhuis
🇳🇱Dordrecht, Netherlands
Maastricht University Medical Centre
🇳🇱Maastricht, Netherlands
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
UMC Utrecht
🇳🇱Utrecht, Netherlands
Christchurch Hospital
🇳🇿Christchurch, New Zealand
Dunedin Hospital
🇳🇿Dunedin, New Zealand
Hutt Hospital
🇳🇿Lower Hutt, New Zealand
Wellington Hospital
🇳🇿Wellington, New Zealand
Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. Szpital Specjalistyczny Barska
🇵🇱Wloclawek, Poland
Melita Medical Sp. z o.o.
🇵🇱Wroclaw, Poland
Centrum Medyczne Oporow
🇵🇱Wroclaw, Poland
Przychodnia Vistamed
🇵🇱Wroclaw, Poland
EuroMediCare Szpital Specjalistyczny z Przychodnia
🇵🇱Wroclaw, Poland
ETG Zamosc
🇵🇱Zamosc, Poland
Centro Hospitalar de Lisboa Norte Hospital Santa Maria
🇵🇹Lisboa, Portugal
Uls Loures Odivelas - Hosp. Loures
🇵🇹Loures, Portugal
Hospital de Portimao-Centro Hospitalar do Barlavento Algarvio
🇵🇹Portimao, Portugal
Centro Hospitalar de Entre o Douro e Vouga, E.P.E
🇵🇹Santa Maria da Feira, Portugal
Uls Gaia Espinho
🇵🇹Vila Nova de Gaia, Portugal
FNsP F.D.R. Banska Bystrica
🇸🇰Banska Bystrica, Slovakia
Cliniq s.r.o.
🇸🇰Bratislava, Slovakia
GASTRO I. s.r.o.
🇸🇰Presov, Slovakia
Gastroenterology Department ENDOMED, s.r.o.
🇸🇰Vranov nad Toplou, Slovakia
Splosna bolnisnica Celje
🇸🇮Celje, Slovenia
Univerzitetni klinicni center Ljubljana
🇸🇮Ljubljana, Slovenia
Worthwhile Clinical Trials Lakeview Hospital
🇿🇦Benoni, South Africa
Mediclinic Panorama
🇿🇦Cape Town, South Africa
Ersta sjukhus
🇸🇪Stockholm, Sweden
Universitatsspital Basel
🇨🇭Basel, Switzerland
Inselspital Universitatsspital Bern
🇨🇭Bern, Switzerland
Gastroenterologische Praxis Balsiger und Seibold
🇨🇭Bern, Switzerland
Kantonsspital St Gallen
🇨🇭St. Gallen, Switzerland
UniversitaetsSpital Zuerich
🇨🇭Zuerich, Switzerland
Changhua Christian Hospital
🇨🇳Changhua, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital, Division of Infectious Diseases
🇨🇳Taipei, Taiwan
Chang-Gung Memorial Hospital, LinKou Branch
🇨🇳Taoyuan, Taiwan
Royal Victoria Hospital
🇬🇧Belfast, United Kingdom
Addenbrooke's Hospital
🇬🇧Cambridge, United Kingdom
Queen Elizabeth University Hospital
🇬🇧Glasgow, United Kingdom
Velocity Clinical Research
🇬🇧High Wycombe, United Kingdom
Chelsea And Westminster Hospital
🇬🇧London, United Kingdom
St George's University Hospital NHS Foundation Trust
🇬🇧London, United Kingdom
John Radcliffe Hospital
🇬🇧Oxford, United Kingdom