The Correlation Between Thrombin Generation Values and Percutaneous Coronary Intervention Results in Active Ischemic Heart Disease Patients.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 128
- Locations
- 1
- Primary Endpoint
- syntax score.
Study Overview
Brief Summary
Cardiovascular diseases are the most common cause of death in the western world. Myocardial infarction pathogenesis usually involves the development of an atherosclerotic plaque and thrombus.
Past research has shown a correlation between thrombin generation values and ischemic heart disease, however, to our knowledge no investigation has been done into the correlation of thrombin generation and cardiac catheterization results in ischemic heart disease patients.
In the current research the investigator will investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients.
Detailed Description
The aim of our study is to investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients.
In total 340 patients are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant. the investigators will measure the thrombin generation over time in plasma assessed by the calibrated automated thrombogram (CAT). In addition information about the course and results of cardiac catheterization will be collected.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Acute coronary syndrome: ST segment elevation myocardial infraction, unstable angina, non ST elevation myocardial infraction or patients presented with chest pain suspect for acute coronary syndrome .
- •planned percutaneous coronary intervention.
- •ability to give Informed consent.
Exclusion Criteria
- •Acute coronary syndrome in the last 6 month prior to current event.
- •thrombophilia
- •pregnancy
- •liver failure or cirrhosis
- •anticoagulant current use
- •active cancer
Outcomes
Primary Outcomes
syntax score.
Time Frame: 1 week
coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients
significant coronary lesion=>70% stenosis or =>50% stenosis in left main.
Time Frame: 1 week
coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients
Secondary Outcomes
- The number of stenotic coronary arteries(1 week)
- Major adverse cardiac events (MACE)(1 year)