The Correlation Between Thrombin Generation Values and Percutaneous Coronary Intervention Results in Active Ischemic Heart Disease Patients.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- syntax score.
研究概览
简要总结
Cardiovascular diseases are the most common cause of death in the western world. Myocardial infarction pathogenesis usually involves the development of an atherosclerotic plaque and thrombus.
Past research has shown a correlation between thrombin generation values and ischemic heart disease, however, to our knowledge no investigation has been done into the correlation of thrombin generation and cardiac catheterization results in ischemic heart disease patients.
In the current research the investigator will investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients.
详细描述
The aim of our study is to investigate the correlation of thrombin generation values using calibrated automated thrombogram and cardiac catheterization results in active ischemic heart disease patients.
In total 340 patients are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant. the investigators will measure the thrombin generation over time in plasma assessed by the calibrated automated thrombogram (CAT). In addition information about the course and results of cardiac catheterization will be collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute coronary syndrome: ST segment elevation myocardial infraction, unstable angina, non ST elevation myocardial infraction or patients presented with chest pain suspect for acute coronary syndrome .
- •planned percutaneous coronary intervention.
- •ability to give Informed consent.
排除标准
- •Acute coronary syndrome in the last 6 month prior to current event.
- •thrombophilia
- •pregnancy
- •liver failure or cirrhosis
- •anticoagulant current use
- •active cancer
结局指标
主要结局
syntax score.
时间窗: 1 week
coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients
significant coronary lesion=>70% stenosis or =>50% stenosis in left main.
时间窗: 1 week
coronary arteries significant stenosis evaluated by percutaneous coronary intervention in ischemic heart disease patients
次要结局
- The number of stenotic coronary arteries(1 week)
- Major adverse cardiac events (MACE)(1 year)