Glossopharyngeal Nerve Block for Post -Tonsillectomy Pain Relief

Not Applicable

Completed

• Conditions: Analgesia
• Interventions: Procedure: bilateral ultrasound guided GPN block

• Registration Number: NCT05435833
• Lead Sponsor: Tanta University

Brief Summary

The aim of the present study is to evaluate the efficacy and safety of Ultra-sound guided submandibular parapharyngeal glossopharyngeal nerve block as regards time for first need of analgesic as a primary outcome as well as pain score, total postoperative analgesic requirement, and incidence of complications as secondary outcomes

Detailed Description

Tonsillectomy is one of the most frequent surgical procedures performed all over the world that has been identified as being severely painful especially in the adult population. Management of post tonsillectomy pain is of paramount importance in order to improve swallowing and enhance oral intake as well as to decrease the risk of dehydration, infection and secondary hemorrhage with a subsequent hastening of recovery.

A variety of analgesic regimens have been implemented to alleviate post-tonsillectomy pain, however; no consensus on the ideal analgesic regimen has been yet identified.

The Ultrasound (US)-guided glossopharyngeal nerve (GPN) block has been acknowledged as a feasible option for providing perioperative analgesia in tonsillectomy patients. It blocks sensory impulses from the posterior third of the tongue, palatine tonsil, and mucous membranes of the mouth and pharynx. Conventional techniques for blocking the GPN carry the risk of vascular puncture, inadvertent block of closely adjacent other cranial nerves, with increased probability of local anesthetic toxicity and even upper airway obstruction. Recently, a novel, safe, and reproducible US-guided GPN block technique has been introduced by Azman et al, which would block the GPN distally, in the tissue plane just next to the pharyngeal wall and relatively far from high risk nearby structures.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2022-06-18
• Study First Submitted QC: 2022-06-23
• Study First Posted: 2022-06-28
• Study Start: 2022-11-05
• Primary Completion: 2023-08-01
• Study Completion: 2023-08-01
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-22
• Last Update Posted: 2023-11-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients classified by the American society of Anesthesiologists ASA I and II patients
• Scheduled for tonsillectomy procedure

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Exclusion Criteria

• Patients' refusal
• History of diabetes mellitus,
• Cardiac, liver or renal impairment
• Obstructive sleep apnea syndrome
• Swallowing difficulty
• Intake of chronic pain medications or substance abuse
• Bleeding disorders
• Hypersensitivity to the used medication

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group I (glossopharyngeal nerve block group)	bilateral ultrasound guided GPN block	bilateral ultrasound guided GPN block will be performed after induction of anesthesia and pre incisional by an experienced anesthesiologist

Primary Outcome Measures

Name	Time	Method
Onset of 1st analgesic request	up to 24 hours postoperative	the time to first analgesic request will be recorded

Secondary Outcome Measures

Name	Time	Method
Pain score	at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours postoperative	The numerical rating scale for pain ranging from 0-10 where the minimum value of 0 represents no pain and the maximum value of 10 represent the worst pain imaginable
Postoperative rescue analgesic consumption	up to 24hours postoperative	Total 24 hours postoperative rescue analgesic consumption

Trial Locations

Locations (1)

Tanta University Hospital; 🇪🇬 Tanta, Gharbia, Egypt