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临床试验/NCT05435833
NCT05435833已完成不适用

Ultrasound-Guided Submandibular Parapharyngeal Glossopharyngeal Nerve Block for Post -Tonsillectomy Pain Relief in Adults. A Prospective Randomized Study

Tanta University2 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2022年11月5日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
50
试验地点
2
主要终点
Onset of 1st analgesic request

研究概览

简要总结

The aim of the present study is to evaluate the efficacy and safety of Ultra-sound guided submandibular parapharyngeal glossopharyngeal nerve block as regards time for first need of analgesic as a primary outcome as well as pain score, total postoperative analgesic requirement, and incidence of complications as secondary outcomes

详细描述

Tonsillectomy is one of the most frequent surgical procedures performed all over the world that has been identified as being severely painful especially in the adult population. Management of post tonsillectomy pain is of paramount importance in order to improve swallowing and enhance oral intake as well as to decrease the risk of dehydration, infection and secondary hemorrhage with a subsequent hastening of recovery.

A variety of analgesic regimens have been implemented to alleviate post-tonsillectomy pain, however; no consensus on the ideal analgesic regimen has been yet identified.

The Ultrasound (US)-guided glossopharyngeal nerve (GPN) block has been acknowledged as a feasible option for providing perioperative analgesia in tonsillectomy patients. It blocks sensory impulses from the posterior third of the tongue, palatine tonsil, and mucous membranes of the mouth and pharynx. Conventional techniques for blocking the GPN carry the risk of vascular puncture, inadvertent block of closely adjacent other cranial nerves, with increased probability of local anesthetic toxicity and even upper airway obstruction. Recently, a novel, safe, and reproducible US-guided GPN block technique has been introduced by Azman et al, which would block the GPN distally, in the tissue plane just next to the pharyngeal wall and relatively far from high risk nearby structures.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
21 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients classified by the American society of Anesthesiologists ASA I and II patients
  • Scheduled for tonsillectomy procedure

排除标准

  • Patients' refusal
  • History of diabetes mellitus,
  • Cardiac, liver or renal impairment
  • Obstructive sleep apnea syndrome
  • Swallowing difficulty
  • Intake of chronic pain medications or substance abuse
  • Bleeding disorders
  • Hypersensitivity to the used medication

结局指标

主要结局

Onset of 1st analgesic request

时间窗: up to 24 hours postoperative

the time to first analgesic request will be recorded

次要结局

  • Pain score(at 30 minutes, 2 hours, 6 hours, 12 hours, and 24 hours postoperative)
  • Postoperative rescue analgesic consumption(up to 24hours postoperative)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mona Blough El Mourad

Assistant professor of Anesthesia, Surgical Intensive Care and Pain Medicine

Tanta University

研究点 (2)

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