Effect of exercise on immune and inflammatory factors in MS patients
Not Applicable
- Conditions
- Multiple sclerosis.Multiple sclerosis
- Registration Number
- IRCT20191006045004N1
- Lead Sponsor
- Shahrekord University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 24
Inclusion Criteria
Confirmed diagnosis of definite relapsing and remitting MS (RRMS)
An Expanded Disability Status Scale (EDSS) Score of 1 to 4
No history of any medical condition, that would preclude participation in the exercise program
Ability to participate in exercise
No Participants in regular exercise in the last 6 months
The age range of 20 - 40 years
Exclusion Criteria
Comorbidities that prevent participation (cardiovascular disease: metabolic disease: etc.)
Corticosteroid treatment
Body injury that they effectively cannot participate in the exercise program
Pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The expression rate of anti-antimicrobial peptides hBD-2 and LL-37. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the hBD-2 and LL-37 variables with methods Real Time-PCR.;Expression rate of micro-RNAS 155; 326; 23b; 146a; 21. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measuring kits for measuring the expression of micro-RNAS 155; 326; 23b; 146a; 21 by method Real Time -PCR.;Expression rate of TLR-4; TLR-2. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the expression of TLR-4 and TLR-2 with Real Time-PCR method.
- Secondary Outcome Measures
Name Time Method Expanded Disability Status Scale. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: EDSS Test.