Early Nutritional Intake and Growth in Very Preterm or Very Low Birth Weight Infants: a Prospective Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Premature
- Sponsor
- Children's Hospital of Fudan University
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Z-scores of weight
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This study aims to explore the relation of early nutritional intake, especially oral nutrition intake, with growth and body composition among very preterm or very low birth weight infants.
Detailed Description
As the survival of very preterm infants increases, it is important to evaluate their long-term outcomes. Nutritional intake during early life was important to the growth and development in infants, especially in preterm infants. Studies found that early nutrition exposure in preterm infants can effect scored of Griffith Mental Development Scales and body fat percentage at later life. Insulin-like growth factor-1, leptin, Ghrelin, C-Peptide are associated with fat mass in children. And accumulation of fat and insulin resistance (IR) in the early postnatal period are related to metabolism diseases in adulthood. However, previous studies on nutrition and growth or the body composition of preterm infants were mostly completed in developed countries, and no relevant data were available in China. Therefore, this study aims to establish a prospective cohort of very preterm infants to observe the effects of nutritional exposure in early life on growth and body composition in later life.
Investigators
Eligibility Criteria
Inclusion Criteria
- •infants born with a gestational age \>=28 weeks and \<32 weeks and/or a birth weight \>=1000g and \<1500g;
- •infants admitted to neonatal intensive care unit (NICU) of Children's hospital of Fudan University within 24h after birth.
Exclusion Criteria
- •major congenital anomalies or heredity metabolic diseases;
- •severe disease or abdominal surgery during hospitalization;
- •death during hospitalization or discharge without medical advice;
- •small for gestational age.
Outcomes
Primary Outcomes
Z-scores of weight
Time Frame: at corrected age 40 gestational weeks
Computed according to the Fenton preterm growth standards (2013)
Secondary Outcomes
- Z-scores of length/height(at corrected age 6 months and 18 months)
- Cognitive development outcome(at corrected age 18 months)
- Body fat free mass(at corrected age 40 gestational weeks and 6 months)
- Z-scores of weight(at corrected age 6 months and 18 months)
- Body fat mass(at corrected age 40 gestational weeks and 6 months)
- Intestinal flora change(from birth to corrected age 18 months)
- Z-scores of head circumference(at corrected age 6 months and 18 months)
- Percentage of infants who achieve catch-up growth(at corrected age 6 months and 18 months)
- Body fat proportion(at corrected age 40 gestational weeks and 6 months)