Exparel (Bupivacaine Liposome Injectable Suspension) for Distal Upper Extremity Blocks in Orthopedic Surgery
Overview
- Phase
- Phase 4
- Intervention
- Exparel Forearm block
- Conditions
- Hand Injuries
- Sponsor
- Jose Soberon, MD
- Enrollment
- 37
- Locations
- 1
- Primary Endpoint
- Onset of Sensorimotor Block
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study is to compare Exparel, a new, long-lasting numbing medication and a shorter-acting nerve block to a traditional single-shot nerve block in patients having hand, wrist or finger surgery.
Investigators
Jose Soberon, MD
Anesthesiologist
Ochsner Health System
Eligibility Criteria
Inclusion Criteria
- •patients 18 years or older having hand, wrist, or finger surgery
- •ability to understand and provide informed consent
- •American Society of Anesthesiologists status I-III
- •presence of a responsible adult caregiver for 48-72 hours after surgery
Exclusion Criteria
- •patient refusal or inability to provide informed consent
- •true allergy, not sensitivity to local anesthetics, midazolam, fentanyl, hydromorphone, propofol
- •pregnancy
- •hepatic or renal failure
- •evidence of infection at or near the proposed needle insertion site
- •any sensorimotor deficit of the upper extremity
- •BMI greater than or equal to 35
- •uncontrolled or severe pulmonary disease
- •anticoagulant use (not aspirin or non-steroidal anti-inflammatories)
- •chronic pain patients
Arms & Interventions
Exparel forearm block
Under ultrasound guidance, 3-5 milliliters (mL) Exparel will be injected around the 3 nerves of the forearm prior to surgery. 20-30 mL Mepivacaine will be used for the supraclavicular block following the forearm block.
Intervention: Exparel Forearm block
Bupivacaine supraclavicular block
Under ultrasound guidance, 20-30 mL 0.5% Bupivacaine will be used for the supraclavicular block.
Intervention: Bupivacaine supraclavicular block
Outcomes
Primary Outcomes
Onset of Sensorimotor Block
Time Frame: 30 minutes
A blinded study staff member will evaluate the subject after the block is performed. Subjects will be asked to move their hand and will be asked if they can feel a sharp sensation on specific areas of their hand. Once no movement and no feeling is detected, the block is considered successful and the time will be noted.