Comparing Different Treatments to Heal Bone Loss Caused by Severe Gum Disease Using Laser Therapy, Natural Proteins, and Growth Factors

Not yet recruiting

Conditions: Chronic periodontitis,

Registration Number: CTRI/2025/04/085914

Lead Sponsor: SIVSRI ROSHAN G M

Brief Summary: **Regenerative Management of Periodontal Intrabony Defects**

Periodontal intrabony defects present a significant clinical challenge, often threatening tooth stability. Regenerative therapies aim to restore lost bone and supporting tissues, improving both function and aesthetics while preserving natural dentition.

**Photobiomodulation (PBM)** at 650 nm offers a non-invasive adjunctive treatment that promotes periodontal regeneration. It enhances fibroblast activity, collagen synthesis, angiogenesis, and growth factor production, while also reducing inflammation. These effects accelerate healing and improve clinical outcomes, including attachment gain and probing depth reduction.

**Enamel Matrix Derivative (EMD)**, derived from developing enamel, stimulates the proliferation and differentiation of cells critical for periodontal regeneration. EMD promotes cementum and periodontal ligament formation, enhances angiogenesis, modulates inflammation, and supports new bone growth, leading to improved clinical attachment and radiographic bone fill.

**Concentrated Growth Factor (CGF)**, an autologous platelet-rich plasma derivative, is rich in growth factors that promote cell proliferation and differentiation. CGF enhances wound healing through angiogenesis and inflammation reduction, contributing to effective bone and tissue regeneration.

Combining PBM, EMD, and CGF may provide a synergistic effect, amplifying individual benefits. PBM improves healing dynamics and growth factor activity, EMD stimulates tissue regeneration, and CGF accelerates repair. Together, they may significantly enhance the regenerative response in intrabony defects, offering a superior alternative to conventional therapies with improved long-term outcomes.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 55

Inclusion Criteria

Patients with an age range of 18 to 60.
Patients with probing pocket depth greater than or equal to 6 mm and clinical attachment loss of greater than or equal to 3 mm.
Patients with 2 walled or 3 walled intrabony defects, with a defect depth of greater than or equal to 3 mm.
Full-mouth plaque score (FMPS) less than 20 percent after phase I therapy Full-mouth bleeding score(FMBS) less than 20 percent after phase I therapy Systemically healthy patients; with no disease that will have a bearing on the outcome of the surgical intervention.

Exclusion Criteria

Patients diagnosed with mal-alignment at the defect site Patients with systemic disease or drugs that contraindicate periodontal surgery.
Patients with a history of smoking and pan chewing.
Sites with advanced furcation involvement.
Pregnant and lactating women.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Clinical Attachment Level gain (CAL) between groups.	Baseline \| 1 month \| 3 month \| 6 month \| 12 month
To evaluate and compare the following clinical outcome measures:	Baseline \| 1 month \| 3 month \| 6 month \| 12 month
2.Probing Pocket Depth (PPD) reduction between groups.	Baseline \| 1 month \| 3 month \| 6 month \| 12 month
3.Radiographic bone fill between the groups	Baseline \| 1 month \| 3 month \| 6 month \| 12 month

Secondary Outcome Measures

Name	Time	Method
To evaluate and compare the position of the gingival crest between the groups.	Baseline

Trial Locations

Locations (1): SRM Dental College Ramapuram
🇮🇳
Chennai, TAMIL NADU, India
SRM Dental College Ramapuram
🇮🇳Chennai, TAMIL NADU, India
DR SIVSRI ROSHAN G M
Principal investigator
7010561672
sivsri1074@gmail.com