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临床试验/NCT03107858
NCT03107858Unknown2 期

The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function

Assiut University1 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2017年11月1日最近更新:
适应症
干预措施

试验速览

阶段
2 期
入组人数
44
试验地点
1
主要终点
serum creatinine

研究概览

简要总结

Renal transplantation is now recognized as a treatment of choice for patients with chronic renal failure with end-stage renal disease. Renal transplantations are associated with better quality of life, better cost/benefit ratio, and possibly longer survival. Significant changes in blood pressure are common throughout the surgical procedure for kidney transplantation. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients scheduled for a living donor kidney transplantation

排除标准

  • Patients (less than 18 years old)
  • Patients' refusal of consenting for enrolment in the study

研究组 & 干预措施

Norepinephrine

Active Comparator

干预措施: Norepinephrine (Drug)

Dopamine

Active Comparator

干预措施: Dopamine (Drug)

结局指标

主要结局

serum creatinine

时间窗: four hours postoperatively

postoperative

次要结局

  • blood urea(four hours postoperatively)
  • renal artery diameter(four hours postoperatively)
  • renal artery blood flow(four hours postoperatively)
  • urine output(over 24 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Abdel Kader Ahmed Mohammed Elkadi

Specialist

Assiut University

研究点 (1)

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