Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer

Active, not recruiting

• Conditions: Neuro-Oncology; MRI Imaging; Tumor Immune Microenvironment

• Registration Number: NCT07185646
• Lead Sponsor: Second Xiangya Hospital of Central South University

Brief Summary

The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI). The primary research question it aims to address is:

• Can multi-modal MRI effectively characterize features of the immune microenvironment in brain tumor patients?

Participants:

Eligible participants who have been diagnosed with a brain tumor will undergo multi-modal MRI scans for detailed assessment of tumor microenvironment features.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Status Verified: 2025-09
• Study First Submitted: 2025-09-15
• Study First Submitted QC: 2025-09-15
• Study First Posted: 2025-09-22
• Last Update Submitted: 2025-09-22
• Last Update Posted: 2025-09-23
• Primary Completion: 2028-12-30
• Study Completion: 2030-12-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. conventional MRI revealed intracranial space-occupying lesions and suspected high-grade gliomas, brain metastases and meningiomas；
2. It is planned to perform a brain tumor resection surgery in this institution.

Exclusion Criteria

1. other CNS diseases in addition to brain tumors;
2. pathologically confirmed brain tumors not belonging to any of the three selected types;
3. contraindications to the use of gadolinium contrast, including hypersensitivity to contrast agents, renal dysfunction, pregnancy or lactation;
4. contraindications to MRI;
5. poor image quality unsuitable for subsequent analyses;
6. age younger than 18 years.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative Progression-Free Survival	6months，12months，24months	Postoperative Progression-Free Survival is defined as the time interval from the date of surgical intervention until the first occurrence of either documented disease progression or death from any cause

Trial Locations

Locations (1)

the Second Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China